| Primary | Change in Net Protein Synthesis | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | g protein/d/kg ffm | | One time at pre-clinisol infusion and one time at post-clinisol infusion | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG003 | 15% CLINISOL 0.08 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) | | OG004 | 15% CLINISOL 0.13 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.13 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG005 | 15% CLINISOL 0.13 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.13 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
| | | Title | Denominators | Categories |
|---|
| Period 1 | - ParticipantsOG0001
- ParticipantsOG0012
- ParticipantsOG0022
- ParticipantsOG003
|
| |
| Secondary | Insulin Sensitivity | | No data available as no data for this outcome measure were collected during the study. | Posted | | | | | | Five times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | |
|
| Secondary | Plasma Concentration of Glucose | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. One subject in grp 0.04 g/kg/hr, seq BA, plasma concentration of glucose was not collected at any time point during Period 1. | Posted | | Mean | Standard Deviation | mg/dL | | Nine times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Serum Concentration of Insulin | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. One subject in grp 0.04 g/kg/hr, seq BA, serum concentration of insulin was not collected at any time point during Period 1. One subject in grp 0.08 g/kg/hr, seq AB, serum concentration of insulin was not collected at the 3hr time point during Period 2. | Posted | | Mean | Standard Deviation | mciu/mL | | Five times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Stable Isotope Enrichment of Phenylalanine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. During both periods (1 and 2), samples were not obtained from any subjects at the 0hr time point. | Posted | | Mean | Standard Deviation | trace/tracee ratio | | Twelve times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Stable Isotope Enrichment of Tyrosine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. During both periods (1 and 2), samples were not obtained from any subjects at the 0hr time point. | Posted | | Mean | Standard Deviation | trace/tracee ratio | | Twelve times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Alanine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Arginine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Aspartic Acid | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Glutamic Acid | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Glutamine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Glycine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Histidine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Isoleucine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Leucine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Lysine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Methionine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Ornithine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
|
| Secondary | Plasma Concentration of Phenylalanine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
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| Secondary | Plasma Concentration of Proline | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
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| Secondary | Plasma Concentration of Serine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
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| Secondary | Plasma Concentration of Taurine | | No data available as no data for this outcome measure were collected during the study. | Posted | | | | | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
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| Secondary | Plasma Concentration of Threonine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
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| Secondary | Plasma Concentration of Tyrosine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
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| Secondary | Plasma Concentration of Valine | | One subject completed Period 1, but withdrew from the study prior to the start of Period 2. | Posted | | Mean | Standard Deviation | micromol/L | | Three times during each 7 hour visit | | | | ID | Title | Description |
|---|
| OG000 | 15% CLINISOL 0.04 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG001 | 15% CLINISOL 0.04 g/kg/hr (BA) | Sequence BA - with Insulin first, then no Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection | | OG002 | 15% CLINISOL 0.08 g/kg/hr (AB) | Sequence AB - without Insulin first, then with Insulin 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection |
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