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The goal of the study is to examine if healthy individuals that ingest St John's wort will have a significantly difference in glucose tolerance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| St John's wort | Experimental | Subjects will undergo 3 oral glucose tolerance tests:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| St John's wort | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| Glucose area under curve (AUC) 0-2 hours | At time=0, the subjects will ingest 75g glucose. Plasma glucose will be measured at 0, 15, 30, 45, 60, 90 and 120 minutes after glucose ingestion. | Glucose concentration 0, 15, 30, 45, 60, 90 and 120 after glucose ingestion |
| Measure | Description | Time Frame |
|---|---|---|
| St John's wort pharmacokinetics | At time=0, the concentration of active components hypericin and hyperforin will be measured. | At time=0 |
| Other metabolic markers | C-peptide and serum insulin will also be measured during the oral glucose tolerance test. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kim Brøsem, Professor, MD | University of Southern Denmark | Study Director |
| Per Damkier, MD PhD | University of Southern Denmark | Principal Investigator |
| Tore B. Stage, MSc Pharm | University of Southern Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark | Odense C | DK-5000 | Denmark |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C422326 | Hypericum extract LI 160 |
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| At time points, 0, 15, 30, 45, 60, 90, 120 minutes after glucose ingestion |
| D004700 | Endocrine System Diseases |