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| ID | Type | Description | Link |
|---|---|---|---|
| NSC 100-2314-B-182A-075 | Other Identifier | National Science Council |
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rTMS over dorsolateral prefrontal cortex is effective in reducing repetitive behaviors in adults with autistic spectrum disorder rTMS over posterior superior temporal sulcus is effective in improving social ability in adults with autistic spectrum disorder
First, we will apply one session intermittent theta burst stimulation over dorsolateral prefrontal cortex, posterior superior temporal sulcus and inion as control with one week interval in adults with autism spectrum disorder. Second, we will apply 5 sessions intermittent theta burst stimulation within one week over dorsolateral prefrontal cortex or posterior temporal sulcus depending on the results of our first phases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| repetitive TMS | Experimental | repetitive TMS over dorsolateral prefrontal cortex, posterior superior temporal sulcus and inion as control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| repetitive TMS | Device | rTMS (intermittent theta burst stimulation 1200)over posterior superior temporal sulcus,dorsolateral prefrontal cortex and inion as Sham control |
|
| Measure | Description | Time Frame |
|---|---|---|
| continuous performance test | continuous performance test will be arranged before and after rTMS within one hour | continuous performance test will be arranged before and after rTMS within one hour |
| Measure | Description | Time Frame |
|---|---|---|
| Yale-Brown Obsessive Compulsive Scale | Yale-Brown Obsessive Compulsive Scale will be evaluated before and after rTMS. The time point of evaluation is before rTMS, one hour after rTMS, 3 days after rTMS and one week after rTMS. | Yale-Brown Obsessive Compulsive Scale will be evaluated before and after rTMS within one week |
| Measure | Description | Time Frame |
|---|---|---|
| Autism Spectrum Quotient | Autism Spectrum Quotient will be evaluated before and after rTMS. The time point of evaluation is before rTMS, one hour after rTMS, 3 days after rTMS and one week after rTMS. | Autism Spectrum Quotient will be evaluated before and after rTMS within one week |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hsing Chang Ni, MD | Contact | 886-3-3281200 | 2479 | alanni0918@yahoo.com.tw |
| Name | Affiliation | Role |
|---|---|---|
| Hsing-Chang Ni, MD | Chang Gung Memorial Hospital at Linkou, Taiwan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang Gung Memorial Hospital | Recruiting | Taoyuan | Taiwan |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 5, 2018 | |
| Reset | Jan 10, 2019 | |
| Release | Jan 24, 2019 | |
| Reset | Apr 26, 2019 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 5, 2018 | Jan 10, 2019 | |||
| Jan 24, 2019 |
| ID | Term |
|---|---|
| D001321 | Autistic Disorder |
| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| Apr 26, 2019 |