A Study of the Efficacy and Safety of Desloratadine (MK-4117) in Japanese Participants With Perennial Allergic Rhinitis (MK-4117-200)

A Phase III, Multi-Center, Randomized, Parallel-Group, Placebo-Controlled and Double- Blind Trial to Study the Efficacy and Safety of MK-4117 in Japanese Subjects With Perennial Allergic Rhinitis

This is a study to evaluate the efficacy and safety of desloratadine (MK-4117) in Japanese participants with perennial allergic rhinitis. The primary hypothesis is that desloratadine is superior to placebo after 2 weeks of treatment with regard to change from baseline in Total Nasal Symptom Score among Japanese participants with perennial allergic rhinitis.

Inclusion Criteria:

• Diagnosed with perennial allergic rhinitis
• Outpatient.

Exclusion Criteria:

• Lower respiratory tract infection or nasopharyngolaryngeal infection (acute upper respiratory tract infection, acute pharyngolaryngitis, or acute tonsillitis, etc.)
• Coexisting infections or systemic mycosis for which there are no effective antibiotics
• Asthma complication under treatment
• Nasal septum ulcers, nasal surgery, or nasal trauma, which has not healed
• Vasomotor rhinitis or eosinophilic rhinitis
• Nasal conditions (infectious sinusitis, hypertrophic rhinitis, acute or chronic rhinitis, nasal polyps, septal deviation, etc.) which may interfere with the evaluation of the efficacy of the study drug
• History of hypersensitivity to antihistamines or study drug
• Currently receiving treatment with another investigational drug or has received an investigational drug in the past 3 months
• Has started specific desensitization therapy or nonspecific allassotherapy (Histaglobin, vaccine therapy, etc.) or who had discontinued such therapies within 90 days (3 months) before the day of obtaining informed consent
• Severe hepatic, renal, cardiac, hematological disease, or other serious coexisting diseases and whose general condition is poor
• History of malignancy or clinically important hematological disorder
• History of severe drug allergy (e.g., anaphylactoid reaction).