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This study involves adolescents operated with arterial switch procedure for transposition of the great arteries during the neonatal period. The purpose is to evaluate the coronary arteries and direct and indirect findings of coronary artery disease/complications with 3 tesla magnetic resonance imaging.
This study involves adolescents operated with arterial switch procedure for transposition of the great arteries during the neonatal period. The patients were operated with two different methods of re-implantation of the coronary arteries ("trap-door"/non-"trap-door", see description below).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Switch "trap-door" re-implantation of the coronaries | Re-implantation of the coronary arteries into the neo-aortic sinuses through a "trap-door" as far distally as possible on the neo-aorta |
| |
| Switch non-"trap-door" re-implantation of the coronaries | Re-implantation of the coronary arteries into the neo-aortic sinuses through small incisions or excision in the sinuses |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3 tesla magnetic resonance imaging findings; coronary artery status | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Direct visualization and status of the coronary arteries, global volume measurements, global and regional strain (myocardial contractility), extravascular, extracellular tissue volume fraction and late enhancement (myocardial fibrosis). | 10-15 years after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of image quality of direct visualization of the coronary arteries with and without contrast enhanced techniques. | 10-15 years after surgery | |
| Comparison of coronary artery findings corresponding to indirect functional and morphological findings in MRI and echocardiography in the left and right ventricle. |
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Inclusion Criteria:
Partial or total Exclusion Criteria:
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Patients 10-15 years old surgically corrected in the neonatal period with arterial switch procedure for transposition of the great arteries at Rikshospitalet, OUS, Norway.
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| Name | Affiliation | Role |
|---|---|---|
| Charlotte De Lange, MD PhD | Oslo University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital, Rikshospitalet | Oslo | 0424 | Norway |
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| 3 tesla magnetic resonance imaging findings; ventricular function and morphology | Other |
|
| 10-15 years after surgery |
| ID | Term |
|---|---|
| D014188 | Transposition of Great Vessels |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D016276 | Ventricular Function |
| ID | Term |
|---|---|
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
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