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This is an observational multi-center study to determine whether any single immune monitoring test or a combination of tests obtained in the first 6 months after renal transplantation correlates with acute rejection or graft loss in renal allograft recipients receiving commonly used immunosuppressive.
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| Measure | Description | Time Frame |
|---|---|---|
| To document the prevalence and frequencies of CD4+ and CD8+ CD28null/NKG2Dpos T cells at the time of transplantation. | 6 months | |
| To test whether CD28null/NKG2Dpos T cells have unique rapid activation properties to allogeneic HLA antigens in vitro | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| To study the clinical correlations between the frequencies of alloreactive CD28null/NKG2Dpos T cells with kidney graft function and histopathology. | 6 months | |
| To test the effects of induction therapy with rabbit anti-thymocyte globulin (ATG) vs. IL-2 receptor blocker antibodies on circulating CD28null/NKG2Dpos T cells. |
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Inclusion Criteria:
Exclusion Criteria:
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Cohort of 80 living and deceased donor kidney transplant recipients and 10 healthy volunteers
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blood/serum
| 6 months |