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This prospective study includes 5 patients with ARDS (Acute Respiratory Distress Syndrome) treated by mechanical ventilation. In case of respiratory acidosis, extracorporeal CO2 (carbon dioxide)removal might be necessary. We hereby work with the Abylcap system with the oxygenator Lilliput2 as CO2 remover (Bellco, Italy).
The patients (M/V) are older than 18, not pregnant, have a BMI<30, and no contraindication for anticoagulation therapy.
Under standard conditions patients are treated with a blood flow of QB=300mL/min and a gas flow (100% 02) of QG=7L/min. Blood sampling is performed from the arterial bloodline in the patients at 0, 1h, 3h, 24h, 48h, 72h, 96h, and 120h.
A parameter study is also performed to optimise CO2 removal. Herewith, blood samples (1mL) are taken from the inlet and outlet line of the Lilliput2 at the previously mentioned time points and for different flow setting: Blood flow (QB) 200-300-400mL/min and gas flow (QG) 1.5, 3, 6, 7, 8L/min
Blood samples are analysed for the different blood gases from which the extraction in the CO2 remover can be calculated for each setting of QB (blood flow) and QG (gas flow).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment with mechanical ventilation | Experimental | Abylcap system with the oxygenator Lilliput2 as CO2 remover (Bellco, Italy). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Abylcap® System: blood flow (QB): 200mL/min; gas flow (QG):7L/min | Device | Abylcap settings |
|
| Measure | Description | Time Frame |
|---|---|---|
| calculation of CO2 extraction in blood samples during mechanical ventilation | Extraction is calculated from the relative difference in blood gases at the inlet and outlet of the CO2 remover. | during mechanical ventilation with CO2 removal (max up to 120h) |
| Measure | Description | Time Frame |
|---|---|---|
| Based on the extraction rates, the optimum parameter settings are derived | Extraction is calculated from the relative difference in blood gases at the inlet and outlet of the CO2 remover. | During mechanical ventilation with CO2 removal (max up to 120h) |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sunny Eloot, PhD, MScBME, MScCivE | University Hospital, Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ghent University Hospital | Ghent | Oost-Vlaanderen | 9000 | Belgium |
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| Abylcap® System: blood flow (QB): 300mL/min; gas flow (QG):7L/min | Device | Abylcap settings |
|
| Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):7L/min | Device | Abylcap settings |
|
| Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):1.5L/min | Device | Abylcap settings |
|
| Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):3L/min | Device | Abylcap settings |
|
| Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):6L/min | Device | Abylcap settings |
|
| Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):8L/min | Device | Abylcap settings |
|
| ID | Term |
|---|---|
| D055371 | Acute Lung Injury |
| D000142 | Acidosis, Respiratory |
| ID | Term |
|---|---|
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012131 | Respiratory Insufficiency |
| D012120 | Respiration Disorders |
| D000138 | Acidosis |
| D000137 | Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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