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| Name | Class |
|---|---|
| National Natural Science Foundation of China | OTHER_GOV |
This study is to examine the change of fasting insulin, glucose, insulin sensitivity and related traits in response to the 14 wk treatment of omega-3 fatty acids, including fish oil (n=25) and flaxseed oil(n=25), in Chinese gestational diabetic patients. Corn oil(n=25), rich in omega-6 fatty acids, will be selected as a controlled oil. The intervention will start from the third trimester of these pregnant women and finish at the 4wk after the birth of their children. The investigators hypothesize that omega-3 fatty acids could improve insulin sensitivity and glucose metabolism in these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| fish oil | Experimental | Patients will receive fish oil capsules, at a dose of 2g/day. Each 1g capsule will contain 220mg of EPA and 170mg of DHA |
|
| Flaxseed Oil | Experimental | Patients will receive flaxseed oil capsule, at a dose of 2g/day. Each 1g capsule will contain 550mg of ALA |
|
| Placebo Supplementation | Placebo Comparator | Patients will receive corn oil in the capsules at the same dose as fish oil. The corn oil will appear identical in size and color to the fish oil |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fish oil | Dietary Supplement |
| ||
| Flaxseed oil |
| Measure | Description | Time Frame |
|---|---|---|
| fasting glucose | 14 weeks | |
| Fasting insulin | 14 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| birth weight, length of children | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| blood lipids, inflammatory markers | 14 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jiaxing Women's and Children's Hospital | Jiaxing | Zhejiang | China |
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| ID | Term |
|---|---|
| D016640 | Diabetes, Gestational |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
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| ID | Term |
|---|---|
| D005395 | Fish Oils |
| D008043 | Linseed Oil |
| ID | Term |
|---|---|
| D009821 | Oils |
| D008055 | Lipids |
| D005224 | Fats, Unsaturated |
| D005223 | Fats |
| D010938 |
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|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D006946 | Hyperinsulinism |
| Plant Oils |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |