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| Name | Class |
|---|---|
| Canadian Lung Association | INDUSTRY |
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The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and muscle metabolism disturbances.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxygen | Experimental |
| |
| Room air | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fatiguing exercise | Other | All participants (patients and healthy subjects) will perform the exercise both under normoxic (FiO2 = 0.21) and hyperoxic conditions (FiO2 = 100%) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Muscle deoxygenation | Changes of deoxyhemoglobin/myoglobin concentrations measured by near-infrared spectroscopy of vastus lateralis muscle. | 45 seconds post-exercise (knee-extension repetitions) |
| Muscle metabolism | Changes in glycolytic and oxidative metabolism pathway markers, energy substrates (glycogen and glucose), end-products of glycolysis (pyruvate, and lactate), intermediate markers of glycolysis and high-energy phosphate compounds obtained from muscle biopsies | 45 seconds post-exercise (knee extension repetitions) |
| Measure | Description | Time Frame |
|---|---|---|
| Ventilatory response | Minute ventilation will be monitored during the fatigue-inducing exercise and it will be compared between subjects and conditions (FiO2 = 21% vs. FiO2 = 100%) | Baseline, beginning and end of each serie of knee extensions (fatiguing exercise) |
| Quadriceps muscle fatigue |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fernanda Ribeiro, PhD candidate | Contact | 418-656-8711 | 3928 | fernanda.ribeiro@criucpq.ulaval.ca |
| Name | Affiliation | Role |
|---|---|---|
| François Maltais, MD | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut universitaire de cardiologie et de pneumologie de Québec | Recruiting | Québec | Quebec | G1V 4G5 | Canada |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Quadriceps muscle fatigue will be determined by loss of quadriceps strength measured by magnetic stimulation after the fatigue-inducing exercise. Surface electromyography will also be measured to characterize muscle fatigue. |
| baseline, 15 min and 40 min after the fatigue-inducing exercise |
| total muscle work | Total muscle work performed during fatigue-inducing exercise that will be composed by subsequent isokinetic knee-extensions repetitions at 40% of maximal peak torque | end of fatiguing exercise |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |