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We previously demonstrated that the slope of the relationship plotting individual iodine loads against contrast-induced serum creatinine changes ( the load-to-damage relationship, LDR) characterizes the intrinsic nephrotoxicity of the contrast. Aim of the present study is to compare, through the assessment of the LDR slope, the intrinsic nephrotoxicity of two different contrast media using serum cystatin-C changes as the LDR dependent variable.
We previously demonstrated that the slope of the relationship plotting individual iodine loads against contrast-induced serum creatinine changes ( the load-to-damage relationship, LDR) characterizes the intrinsic nephrotoxicity of the contrast and it may allow for reliable comparative evaluations among small sized study groups randomized to different contrast media. The aim of the present study is to compare, through the assessment of the LDR slope, the intrinsic nephrotoxicity of two different contrast media using serum cystatin-C changes as the LDR dependent variable.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Iodixanol | Active Comparator | Patients randomized to coronary angiography/angioplasty with Iodixanol 320 |
|
| Iobitridol | Active Comparator | Patients randomized to coronary angiography/angioplasty with Iobitridol 350 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Iobitridol 350 | Drug |
| ||
| Iodixanol 320 |
| Measure | Description | Time Frame |
|---|---|---|
| Slope of LDR (as assessed by serum cystatin-C changes) | Slope of the relationship plotting individual iodine loads against serum cystatin-C changes at 48 hours after catheterization | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Slope of LDR (as assessed by serum creatinine changes) | Slope of the relationship plotting individual iodine loads against serum creatinine changes at 72 hours after catheterization | 72 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Misericordia Hospital, ASL 9 | Grosseto | 58100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23811842 | Background | Limbruno U, Picchi A, Micheli A, Calabria P, Cortese B, Brizi G, Severi S, De Caterina R. Refining the assessment of contrast-induced acute kidney injury: the load-to-damage relationship. J Cardiovasc Med (Hagerstown). 2014 Jul;15(7):587-94. doi: 10.2459/JCM.0b013e3283638e56. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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|
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |