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Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.
Therefore the purpose of this study is to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ischemic Preconditioning | Experimental | IPC (4 x 5 minute cycles @ 220 mmHg) with 5 min reperfusion between trials. |
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| Ischemic Preconditioning Placebo | Placebo Comparator | Placebo (4 x 5 minute cycles @ 20mmHg) with 5 minutes between each cycle |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ischemic Preconditioning | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in maximal voluntary contraction | Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition. The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions. | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Creatine kinase | Plasma CK was determined from an earlobe capillary blood sample. The sample (10 microlitres) was analysed immediately using an semi-automated clinical chemistry analyser. The change in CK will be determined 24, 48 and 72 hours following pre exercise conditions | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St Marys Umiversity College | London | TW1 4SX | United Kingdom |
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| ID | Term |
|---|---|
| D019194 | Ischemic Preconditioning |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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| Change from baseline in Limb girth | Mid-thigh and calf circumference was assessed as a measure of limb swelling using an anthropometric tape measure. Both measures were obtained with the participant in a standing position. The change in limb girth will be determined 24, 48 and 72 hours following pre exercise conditions | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise |
| Chnage from baseline in Vertical jump | Vertical jump (VJ) performance was assessed using an electronic timing mat with hands placed on hips and participants dropping down to a self-selected level before jumping maximally. The change in VJ will be determined 24, 48 and 72 hours following pre exercise conditions | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise |
| Change from baseline in Muscle soreness | Muscle soreness - Participants were asked to perform and hold a squat (90° knee angle) whilst they rated their perceived muscle soreness on a 200 mm visual analogue scale. The scale consisted of a line from 0 mm (no pain) to 200 mm (unbearably painful). The change in muscle soreness will be determined 24, 48 and 72 hours following pre exercise conditions | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise |