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Implantable cardioverter defibrillators (ICD) may have the capacity to provoke or worsen ventricular tachyarrhythmias (VT). It has been reported that ICD shocks by itself can increase mortality. This study aimed to determine the role of back-up pacing-induced VT (PIT) to the overall ICD shock burden by avoiding pause-related ventricular back-up pacing by programming the pacing output to a sub-threshold level for ineffective pacing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with PIT | Identification of patients with pacemaker-induced ventricular tachycardias |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Programming the pacemaker output for ventricular back-up pacing to a sub-threshold level | Other | Programming the pacemaker output for ventricular back-up pacing to a sub-threshold level to achieve an ineffective pacing output |
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of VT requiring ICD shock | Patients were followed-up for the occurrence of ventricular tachycardia requiring ICD shock therapy | 48 months follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Type of arrhythmia / Number of arrhythmia | Analysis of the number and the types of recurrent arrhythmias requiring ICD shock termination | 48 months |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of PIT versus other VTs | Measurement of the proportion of PIT versus other VTs requiering ICD shock termination | 48 months |
Inclusion Criteria:
Exclusion Criteria:
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Patients having an implanted ICD for secondary prevention of ventricular tachyarrhythmias. Patients are routinely under follow-up for device interrogation in our outpatient device department.
Patients with identified pacemaker-induced ventricular tachycardia were selected and after two or more episodes of VT, the ventricular back-up pacing was reprogrammed to a sub-threshold level.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Mainz, II. Medical Clinic, Dept. of Electrophysiology | Mainz | D-55131 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24654876 | Derived | Theis C, Mollnau H, Sonnenschein S, Konrad T, Himmrich E, Bock K, Schulz E, Kampfner D, Gerhardt S, Quesada Ocete B, Munzel T, Rostock T. Reduction of ICD shock burden by eliminating back-up pacing induced ventricular tachyarrhythmias. J Cardiovasc Electrophysiol. 2014 Aug;25(8):889-895. doi: 10.1111/jce.12418. Epub 2014 May 2. |
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| ID | Term |
|---|---|
| D017180 | Tachycardia, Ventricular |
| D012769 | Shock |
| ID | Term |
|---|---|
| D013610 | Tachycardia |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| D000075224 |
| Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |