Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity.
This will be achieved by integrating a functional neuroimaging (fMRI) with behavioral reward tasks and the modulation of the dopamine level by dopamine depletion.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| subjecst with different BMI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dopamine depletion vs. Balanced aminoacid drink | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differential brain functions in the dopaminergic reward system | differential brain fuctions will be measured by blood oxygen level dependent effect. | 4 hours after intake of the dopamine depletion or balanced aminoacid drink |
| Measure | Description | Time Frame |
|---|---|---|
| amino acid level changes due to dopamine depletion | 4 hours after intake of the dopamine depletion or balanced aminoacid drink |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
community sample
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Clinic of Tuebingen, MEG Center | Tübingen | 72076 | Germany |
Not provided
| ID | Term |
|---|---|
| D009765 | Obesity |
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |