This study will assess the safety, tolerability, and pharmacokinetics (PK) of orally administered ALS-008176 in healthy volunteers.

Inclusion Criteria:

• Male or female subjects, 18-55 years of age, in good health with screening laboratory values within limits specified by the protocol
• Body mass index 18-30 kg/m2
• Female subjects must be of non-childbearing potential; male subjects must be surgically sterile or practicing birth control

Exclusion Criteria:

• Clinically significant or uncontrolled medical illness
• Use, or anticipated use during conduct of the study, of concomitant medications