Study of Single and Multiple Doses of ALS-008176 in Healthy Volunteers

A Randomized, Double-blind, Placebo-controlled, First-in-human, 3-Part Study of Orally Administered ALS-008176 to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Dosing, Multiple Ascending Dosing and Food-effect in Healthy Volunteers

This study will assess the safety, tolerability, and pharmacokinetics (PK) of orally administered ALS-008176 in healthy volunteers.

Inclusion Criteria:

• Male or female subjects, 18-55 years of age, in good health with screening laboratory values within limits specified by the protocol
• Body mass index 18-30 kg/m2
• Female subjects must be of non-childbearing potential; male subjects must be surgically sterile or practicing birth control

Exclusion Criteria:

• Clinically significant or uncontrolled medical illness
• Use, or anticipated use during conduct of the study, of concomitant medications