Funding not secured. IRB approval has been withdrawn as of January 2017.

Sensory gating is defined as the automatic process of inhibiting brain response to repeated auditory sounds. Infants who brains respond similarly to two identical sounds presented about 1/2 second apart are more likely to have later problems with attention than infants who suppress response to the second sound. This study will examine whether providing a nutritional supplement, phosphatidylcholine, for two months in infancy will result in an increased likelihood of developing more robust sensory gating.

Inclusion Criteria:

• Healthy infant has an age (adjusted for gestational age at birth) of 1-7 weeks
• Diminished P50 sensory gating (ratio greater than or equal to 0.50)

Exclusion Criteria:

• No maternal reported tobacco use for greater than 1 year and no current tobacco use (as measured by urine cotinine levels)
• Trimethylaminuria, renal disease, liver disease, known chromosomal abnormality, chronic neurological disorder, premature birth, prenatal exposure to exogenous steroid use