The hypotheses of our research are based on the fact that various pathological states, infection, cancer, inflammatory disease, can induce an inflammatory syndrome, through different pathways, even though the clinical presentation can be identical. The identification of biological markers specific to an etiology would therefore allow a faster diagnosis and improve care for patients. We thus took an interest in the three groups of diseases most frequently responsible for an inflammatory syndrome, infections, cancers and auto-immune diseases. To achieve this, various methods will be used.

Inclusion Criteria:

Patients presenting an inflammatory syndrome, defined by elevated C-reactive protein (CRP>50mg/L), whose etiology is related to infection, cancer or an inflammatory disease.

• Patients not on treatment (corticoids, immunosuppressive drugs) during the 7 days preceding inclusion
• Age: 18-90 years
• Patients covered by the National Health Insurance Agency
• signed written informed consent form

Exclusion Criteria:

• - Any patient not meeting the inclusion criteria
• Pregnant patients