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| Name | Class |
|---|---|
| Weill Medical College of Cornell University | OTHER |
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This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.
Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obese subjects for fat biopsy | 10 patients recruited during fat biopsies for sample collection |
| |
| Lean controls for fat biopsy | 5 Lean controls will be recruited |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fat Biopsy | Procedure | Fat biopsy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy | Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy | Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy | 1 day |
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Inclusion Criteria:
-Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol
Exclusion Criteria:
-History of any skin disease
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Healthy Volunteer and obese subjects
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| Name | Affiliation | Role |
|---|---|---|
| Jose Aleman, MD PhD | Rockefeller Univesrity | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Rockefeller University | New York | New York | 10065 | United States |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Adipose tissue
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |