The aim of this study is to verify that the frequency of pancreatic fistula (ISGPF grade B and C) in horizontal mattress suture are lower than in interrupted suture during pancreaticojejunostomy in pancreatoduodenectomy by randomized clinical trial.

Inclusion Criteria:

Patients from whom we obtained written informed consent of this study

Exclusion Criteria:

• Patients with severe ischemic cardiac disease
• Patients with severe liver damage
• Patients requiring oxygen administration due to interstitial pneumonia or pulmonary fibrosis
• Patients requiring dialysis treatment due to chronic renal failure
• Patients who are considered as inappropriate by attending physician