ALS is a severe progressive neurodegenerative disease characterized by degeneration motor neurons leading to death in 3 to 5 years. Gradually in time, the patient deprived of all motor skills as well as the possibility of communication written and oral developing a state close Locked In Syndrome (LIS). The main objective is to establish the feasibility of brain-computer interface using the pathological condition, with dependent disabled subjects as a means of communication.

Inclusion Criteria:

• age >= 18
• have a diagnosis of ALS suspected, possible, probable with EMG
• be able to follow the study process and to comply with the schedule of visits upon entry into the study
• understand the purpose of the study
• expressing P300 wave in the conditions of the study

Exclusion Criteria:

• have a mental illness or clinical dementia defined clinically significant may hinder the patient's ability to follow the procedures of the study
• have a significant history of photosensitive epilepsy
• have a history of allergy to the gel used for the electrodes
• Major protected by law (guardianship, curators)
• have uncorrectable visual disorders
• not being able to maintain a sitting position and focus on a computer screen for more than 30 min.