Myocardial Micro-damage in Relation to Active and Passive Fixation Pacemaker Electrodes

Effect of Passive Versus Active Fixation Leads on the Magnitude of Troponin Release After Pacemaker Implantation (PACMAN Trial)

Pacemaker electrodes are either equipped with tines (passive fixation) or with a screw (active fixation) for initial fixation in the patient´s heart. Both types of electrodes provide similar results in a long-term follow-up and the use of one or the other electrode type in many instances is mainly based on the implanter´s preference. The PACMAN-trial investigates whether the two lead types are associated with different amounts of myocardial micro-damage during implantation.

Inclusion Criteria:

• de-novo implantation of a pacemaker system

Exclusion Criteria:

• AAI pacing or cardiac resynchronization therapy
• ICD indication
• temporary pacing
• lead revision
• right ventricular pacing aimed from alternative pacing sites (other than the apex)
• lead revision
• severe tricuspid valve regurgitation
• previous myocardial infarction, coronary intervention, stroke, cardioversion or ablation in the presence of elevated troponin levels
• dialysis