Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA) | NCT01897532 | Trialant

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA) | NCT01897532 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion criteria:

Documented diagnosis of T2DM before visit 1(screening).

Male or female patients who are drug-naïve or pre-treated with any antidiabetic background medication, excluding treatment with Glucagon-like Peptide 1 (GLP-1) receptor agonists, Dipeptidyl-peptidase 4 (DPP-4) inhibitors or Sodium Glucose Linked Transporter 2 (SGLT-2) inhibitors if => consecutive 7 days.

Stable antidiabetic background medication (unchanged daily dose) for at least 8 weeks prior to randomization. If insulin is part of the background therapy, the average daily insulin dose should not have changed by more than 10% within the 8 weeks prior to randomization compared with the daily insulin dose at randomization.

HbA1c of => 6.5% and <= 10.0% at Visit 1 (screening)

Age => 18 years at Visit 1(screening). For Japan only: Age => 20 years at Visit 1

Body Mass Index (BMI) <= 45 kg/m2 at Visit 1 (screening)

Signed and dated written informed consent by date of Visit 1(screening) in accordance with Good Clinical Practice (GCP) and local legislation prior to any study related procedure

High risk of cardiovascular (CV) events defined by: 1) albuminuria (micro or macro) and previous macrovascular disease and/or 2) impaired renal function with predefined Urine Albumin Creatinine Ratio (UACR)

Exclusion criteria:

Type 1 diabetes mellitus.

Treatment (=> 7 consecutive days) with GLP-1 receptor agonists, other DPP-4 inhibitors or SGLT-2 inhibitors prior to informed consent. Note: This also includes clinical trials where these antidiabetic drugs have been provided to the patient.

Active liver disease or impaired hepatic function, defined by serum levels of either Alanine Transaminase (ALT) (SGPT), Aspartate transaminase (AST) (SGOT), or alkaline phosphatase (AP) => 3 x upper limit of normal (ULN) as determined at Visit 1.

Estimated Glomerular filtration Rate (eGFR) <15 ml/min/1.73 m2 (severe renal impairment or End Stage Renal Disease (ESRD), Modification of Diet in Renal Disease (MDRD) formula), as determined during screening at Visit 1 and/or the need for maintenance dialysis.

Any previous (or planned within next 12 months) bariatric surgery (open or laparoscopic) or intervention (gastric sleeve).

Pre-planned coronary artery re-vascularisation (PCI, CABG) or any previous PCI and/or CABG <= 2 months prior informed consent.

Known hypersensitivity or allergy to the investigational products or its excipients.

Any previous or current alcohol or drug abuse that would interfere with trial participation in the opinion of the investigator.

Participation in another trial with an investigational drug ongoing or within 2 months prior to visit 1 (screening).

Pre-menopausal women (last menstruation = 1 year prior to informed consent) who are nursing or pregnant, are of child-bearing potential and are not practicing an acceptable method of birth control (acceptable methods of birth control include tubal ligation, transdermal patch, intra uterine devices/systems (IUDs/IUSs), oral, implantable or injectable contraceptives, sexual abstinence (if allowed by local authorities), double barrier method and vasectomised partner) or do not plan to continue using acceptable method of birth control throughout the study and do not agree to submit to periodic pregnancy testing during participation in the trial.

Patients considered unreliable by the investigator concerning the requirements for follow up during the study and/or compliance with study drug administration, have a life expectancy less than 5 years for non-CV causes, or have cancer other than non-melanoma skin cancer within last 3 years, or has any other condition than mentioned which in the opinion of the investigator, would not allow safe participation in the study.

Acute coronary syndrome (ACS), diagnosed <= 2 months prior to visit 1 (screening).

Stroke or Transient Ischemic Attack (TIA) <= 3 months prior to visit 1 (screening).

Longwood Research

Huntsville, Alabama 35801, United States

Scottsboro Quick Care Clinic

Scottsboro, Alabama 35768, United States

Office of Dr. Terence T. Hart MD

Tuscumbia, Alabama 35674, United States

Arrowhead Health Centers

Glendale, Arizona 85306, United States

Precision Trials, LLC

Phoenix, Arizona 85032, United States

Harrisburg Family Medical Center

Harrisburg, Arkansas 72432, United States

Cardiology and Medicine Clinic

Little Rock, Arkansas 72204, United States

Little Rock Diagnostic Clinic

Little Rock, Arkansas 72205, United States

Kaiser Permanente - San Diego, Bonita

Bonita, California 91902, United States

John Muir Physician Network Clinical Research Center

Concord, California 94520, United States

Valley Research

Fresno, California 93720, United States

VA Loma Linda Healthcare System

Loma Linda, California 92357, United States

Long Beach Center for Clinical Research

Long Beach, California 90807, United States

Clearview Medical Research, LLC

Los Angeles, California 90019, United States

National Research Institute

Los Angeles, California 90057, United States

Office of Dr. Richard S. Cherlin

Los Gatos, California 95032, United States

Coastal Medical Research Group

Los Osos, California 93402, United States

Novo Research, Incorporated

Modesto, California 95350, United States

Providence Clinical Research

North Hollywood, California 91606, United States

Northridge Clinical Research Inc.

Northridge, California 91324, United States

Carr Cardiology

Oceanside, California 92056, United States

Center for Clinical Trials of Sacramento, Incorporated

Sacramento, California 95823, United States

North America Research Institute

San Dimas, California 91773, United States

Trinitas Research, Incorporated

San Jose, California 95116, United States

Metabolic Institute of America

Tarzana, California 91356, United States

Center for Clinical Trials of San Gabriel

West Covina, California 91790, United States

Western Nephrology & Metabolic

Arvada, Colorado 80002, United States

South Denver Nephrology

Denver, Colorado 80210, United States

Colorado Center for Bone Research, P.C.

Golden, Colorado 80401, United States

Helix Biomedics LLC

Boynton Beach, Florida 33435, United States

Orthopedic Research Institute

Boynton Beach, Florida 33437, United States

Nova Clinical Research, LLC

Bradenton, Florida 34209, United States

PAB Clinical Research

Brandon, Florida 33511, United States

Meridien Research

Brooksville, Florida 34601, United States

Southeast Clinical Research, LLC

Chiefland, Florida 32626, United States

BayCare Medical Group

Clearwater, Florida 33756, United States

Cohen Medical Research Associates, LLC

Delray Beach, Florida 33446, United States

Innovation Medical Research Center, Inc

Doral, Florida 33166, United States

Integrative Research Associates

Fort Lauderdale, Florida 33312, United States

Jellinger and Lerman, MD, PA dba The Center for Diabetes and Endocrine Care

Fort Lauderdale, Florida 33312, United States

Direct Helpers Medical Center, Inc

Hialeah, Florida 33012, United States

Universal Clinical Research

Hialeah, Florida 33012, United States

Homestead Associates in Research

Homestead, Florida 33032, United States

St. Vincent's Cardiology

Jacksonville, Florida 32216, United States

Care Partners Clinical Research LLC

Jacksonville, Florida 32277, United States

Altus Research, Inc.

Lake Clarke Shores, Florida 33406, United States

Meridien Research

Lakeland, Florida 33805, United States

Clinical Research of Miami

Miami, Florida 33126, United States

Prestige Clinical Research Center, Inc.

Miami, Florida 33133, United States

Jesscan Medical Research, Internal Medicine

Miami, Florida 33134, United States

Clintex Research Group, Inc. Research

Miami, Florida 33135, United States

University of Miami

Miami, Florida 33136, United States

Florida Medical Center & Research Inc

Miami, Florida 33142, United States

A+ Research Incorporated

Miami, Florida 33144, United States

Unlimited Medical Research, LLC

Miami, Florida 33144, United States

Regenerate Clinical Trials

Miami, Florida 33155, United States

Sanitas Research

Miami, Florida 33155, United States

Future Care Solution, LLC

Miami, Florida 33165, United States

Research Institute of South Florida Inc

Miami, Florida 33173, United States

Tellus Clinical Research, Incorporated

Miami, Florida 33173, United States

New Horizon Research Center

Miami, Florida 33175, United States

Kendall South Medical Center, Inc

Miami, Florida 33185, United States

Coral Research Clinic Corp

Miami, Florida 33186, United States

Precision Research Organization

Miami Lakes, Florida 33016, United States

School of Clinical Research

North Miami Beach, Florida 33144, United States

Harmony Clinical Research, Incorporated

North Miami Beach, Florida 33162, United States

Magnolia Research Group

Ocala, Florida 34471, United States

Family Medical Center

Orlando, Florida 32806, United States

Peninsula Research, Inc.

Ormond Beach, Florida 32174, United States

Infinity Clinical Research, LLC

Plantation, Florida 33317, United States

Intercoastal Medical Group, Endocrinology

Sarasota, Florida 34232, United States

Meridien Research

St. Petersburg, Florida 33709, United States

Professional Health Care of Pinellas, Inc.

St. Petersburg, Florida 33713, United States

Meridien Research

Tampa, Florida 33634, United States

Metabolic Research Institute

West Palm Beach, Florida 33401, United States

Emory University

Atlanta, Georgia 30303, United States

Laureate Clinical Research Group, LLC

Atlanta, Georgia 30308, United States

Bainbridge Medical Associates

Bainbridge, Georgia 39819, United States

Atlanta Heart Specialists, LLC

Cumming, Georgia 30041, United States

McGarity, Jr., William C.

Decatur, Georgia 30035-4000, United States

Atlanta Heart Specialists, LLC

Tucker, Georgia 30084, United States

Belleville Family Medical Associates, Ltd

Belleville, Illinois 62220, United States

Cedar-Crosse Research Center

Chicago, Illinois 60607, United States

Chicago Clinical Research Institute, Inc.

Chicago, Illinois 60607, United States

Associates in Endocrinology, Incorporated

Elgin, Illinois 60124, United States

Kidney Care Center, Nephrology

Joliet, Illinois 60435, United States

American Health Network

Avon, Indiana 46123, United States

American Health Network of Indiana, LLC

Franklin, Indiana 46131, United States

American Health Network of Indiana, LLC

Greenfield, Indiana 46140, United States

American Health Network of Indiana, LLC

Muncie, Indiana 47304, United States

Buynak Clinical Research

Valparaiso, Indiana 46383, United States

Northeast Iowa Medical Education Foundation

Waterloo, Iowa 50702, United States

Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa 50265, United States

Cotton-O'Neil Clinical Research Center

Topeka, Kansas 66606, United States

Professional Research Network of Kansas, LLC

Wichita, Kansas 67203, United States

Heartland Research Associates, LLC

Wichita, Kansas 67205, United States

The Research Group of Lexington, LLC

Lexington, Kentucky 40503, United States

Diabetes and Metabolism Associates APMC

Metairie, Louisiana 70006, United States

Tulane University Hospital and Clinic

New Orleans, Louisiana 70112, United States

Maryland Cardiovascular Specialists

Baltimore, Maryland 21229, United States

Overlea Personal Physicians

Baltimore, Maryland 21236, United States

Johns Hopkins University

Baltimore, Maryland 21287, United States

Delmarva Heart Research Foundation, Inc

Salisbury, Maryland 21804, United States

Endeavor Medical Research

Alpena, Michigan 49707, United States

University of Michigan Health System

Ann Arbor, Michigan 48105, United States

Aa Mrc Llc

Flint, Michigan 48504, United States

McLaren Northern Michigan Hospital

Petoskey, Michigan 49770, United States

Remedica LLC

Rochester, Michigan 48307, United States

Tri-County Research, Inc

Sterling Heights, Michigan 48310-3503, United States

Oakland Medical Research Center

Troy, Michigan 48085, United States

HealthEast St. Joseph's Hospital

Saint Paul, Minnesota 55102, United States

Mississippi Medical Research, LLC

Carriere, Mississippi 39426, United States

Truman Medical Centers, Inc.

Kansas City, Missouri 64108, United States

Kansas City Veterans Administration Medical Center

Kansas City, Missouri 64128, United States

Glacier View Cardiology, PC

Kalispell, Montana 59901, United States

Platte River Nephrology

North Platte, Nebraska 69101, United States

Omaha Veterans Affairs Medical Center

Omaha, Nebraska 68131, United States

Alas Science Clinical Research

Las Vegas, Nevada 89120, United States

USMA Clin. Research/Union Square Med. Associates

Elizabeth, New Jersey 07201, United States

Mount Sinai - PRIME

Linden, New Jersey 07036, United States

New Mexico Clinical Research and Osteoporosis Center, Inc.

Albuquerque, New Mexico 87106, United States

Life Medi-Research and Management

Brooklyn, New York 11206, United States

United Medical Associates

Johnson City, New York 13901, United States

Saratoga Clinical Research, LLC

Saratoga Springs, New York 12866, United States

Jacobi Medical Center

The Bronx, New York 10461, United States

Kernodle Clinic West

Burlington, North Carolina 27215, United States

Main Street Physicians Care

Calabash, North Carolina 28467, United States

Box Arthritis & Rheumatology of the Carolinas

Charlotte, North Carolina 28210, United States

Clinical Research of Gastonia

Gastonia, North Carolina 28054, United States

Medication Management, LLC

Greensboro, North Carolina 27408, United States

PMG Research of Bristol, LLC

Hickory, North Carolina 28601, United States

Novant Health Southern Piedmont Primary Care

Monroe, North Carolina 28110, United States

Research Institute of the Carolinas, PLC

Mooresville, North Carolina 28117, United States

Down East Medical Associates

Morehead City, North Carolina 28557, United States

Burke Primary Care

Morganton, North Carolina 28655, United States

PMG Research of Salisbury, LLC

Salisbury, North Carolina 28144, United States

Natalie A Doyle, M.D., P.A.

Wilson, North Carolina 27893, United States

Summa Health System

Akron, Ohio 44304, United States

Medical Frontiers, LLC

Carlisle, Ohio 45005, United States

Dayton VA Medical Center

Dayton, Ohio 45428, United States

Norton Community Care

Norton, Ohio 44203, United States

Apex Medical Research, AMR, Incorporated

Springfield, Ohio 45505, United States

ProMedica Health Education & Research Corp.

Toledo, Ohio 43606, United States

COR Clinical Research, LLC

Oklahoma City, Oklahoma 73103, United States

Lynn Health Science Institute

Oklahoma City, Oklahoma 73112, United States

The Corvallis Clinic, PC

Corvallis, Oregon 97330, United States

Blair Medical Associates

Altoona, Pennsylvania 16602, United States

Clinical Research Associates of Central Pennsylvania

Altoona, Pennsylvania 16602, United States

Central Bucks Cardiology

Doylestown, Pennsylvania 18901, United States

Doylestown Health Cardiology

Doylestown, Pennsylvania 18901, United States

Lycoming Internal Medicine, Inc

Jersey Shore, Pennsylvania 17740, United States

Montgomery Medical Incorporated

Smithfield, Pennsylvania 15478, United States

Clinical Trials of South Carolina

Charleston, South Carolina 29406, United States

Medical University of South Carolina

Charleston, South Carolina 29425, United States

Spectrum Medical Research, LLC

Gaffney, South Carolina 29341, United States

VitaLink Research

Greenville, South Carolina 29615, United States

Mountain View Clinical Research

Greer, South Carolina 29651, United States

Vita Link Research- Rock Hill

Rock Hill, South Carolina 29732, United States

Health Concepts

Rapid City, South Dakota 57702, United States

Holston Medical Group

Bristol, Tennessee 37620, United States

State of Franklin Healthcare Associates, PLLC

Johnson City, Tennessee 37604, United States

DCT- AACT, LLC dba Discovery Clinical Trials

Austin, Texas 78758, United States

Rockwood Medical Clinic

Bedford, Texas 76022, United States

Texas Health Physicians Group

Dallas, Texas 75218, United States

Research Institute of Dallas

Dallas, Texas 75231, United States

Ben Taub General Hospital

Houston, Texas 77030, United States

Southwest Clinical Trials

Houston, Texas 77074, United States

The Endocrine Center

Houston, Texas 77079, United States

Texas Family Geriatrics Clinic

Houston, Texas 77082, United States

Memorial Clinical Associates Research

Houston, Texas 77084, United States

Break Through Medical Research

Irving, Texas 75039, United States

Medical & Surgical Clinic

Irving, Texas 75061, United States

West Memorial Family Practice

Katy, Texas 77450, United States

Hill Country Medical Associates

New Braunfels, Texas 78130, United States

Permian Research Foundation

Odessa, Texas 79761, United States

Methodist Hospital Research Institute, Internal Medicine

Pearland, Texas 77584, United States

Health Texas Research Institute

San Antonio, Texas 78228-6205, United States

Covenant Clinical Research, PA

San Antonio, Texas 78229, United States

DM Clinical Research

San Antonio, Texas 78249, United States

DCT-Stone Oak, LLC dba Discovery Clinical Trials

San Antonio, Texas 78258, United States

Sealy Urgent Care Center and Medical Clinic

Sealy, Texas 77474, United States

Pioneer Research Solutions, Inc.

Sugar Land, Texas 77479, United States

DM Clinical Research

Tomball, Texas 77375, United States

Crossroads Clinical Research, LLC

Victoria, Texas 77901, United States

Ericksen Research & Development, LLC

Clinton, Utah 84015, United States

Focus Clinical Research

Draper, Utah 84020, United States

Advanced Research Institute

Ogden, Utah 84405, United States

Paramount Medical Care

Ogden, Utah 84405, United States

Burke Internal Medicine and Research

Burke, Virginia 22015, United States

Nova Health Management & Research Group, PC

Herndon, Virginia 20170, United States

Manassas Clinical Research Center

Manassas, Virginia 20110, United States

Dominion Medical Associates, Inc.

Richmond, Virginia 23219, United States

Hunter Holmes McGuire Veterans Administration Medical Center

Richmond, Virginia 23249, United States

Roanoke Heart Institute PLC

Roanoke, Virginia 24014, United States

Salem Veterans Affairs Medical Center

Salem, Virginia 24153, United States

Sound Medical Research

Port Orchard, Washington 98366, United States

Zablocki VA Medical Center

Milwaukee, Wisconsin 53295, United States

Instituto Médico Adrogué

Adrogué, B1846DSK, Argentina

Hospital Interzonal General de Agudos Dr Jose Penna

Bahía Blanca, 8000, Argentina

Inst de Inv Clinicas-Bahia Blanca

Bahía Blanca, B8000FTD, Argentina

Hospital Italiano Regional del Sur, Bahia Blanca

Bahía Blanca, B8001HXM, Argentina

Hospital Sirio-Libanés

Caba, C1419GEP, Argentina

Centro de Investigaciones Metabólicas

Ciudad Autonoma Buenos Aires, C1056ABJ, Argentina

CIPREC

Ciudad Autonoma Buenos Aires, C1119ACN, Argentina

Hospital Italiano

Ciudad Autonoma Buenos Aires, C1181ACH, Argentina

Consultorios Asociados de Endocrinología e Invest Clínica

Ciudad Autonoma Buenos Aires, C1425AGC, Argentina

CEDIC - Centro de Investigacion Clinica

Ciudad Autonoma Buenos Aires, C1425DES, Argentina

Instituto Cardiovascular de Buenos Aires

Ciudad Autonoma Buenos Aires, C1428ART, Argentina

CCBR - Buenos Aires - AR

Ciudad Autonoma Buenos Aires, C1430CKE, Argentina

Centro Médico Viamonte

Ciudad Autonoma de Bs As, C1120AAC, Argentina

Centro Universitario de Investigacion Corrientes

Corrientes, W3400, Argentina

Centro Médico Colon

Córdoba, 5000, Argentina

CEMAIC - Centro Medico Especializado

Córdoba, 5008, Argentina

Inst. Privado de Inv. Clínicas de Córdoba

Córdoba, X5000AAW, Argentina

Sanatorio Allende S.A.

Córdoba, X5000JHQ, Argentina

Clínica Colombo

Córdoba, X5002AOQ, Argentina

Instituto DAMIC - Fundacion Rusculleda

Córdoba, X5003DCE, Argentina

Hospital Cordoba

Córdoba, X5004CDT, Argentina

IPAC - Clínica Privada Caraffa SRL

Córdoba, X5008KKF, Argentina

Clinica Privada del Prado

Córdoba, X5020AAA, Argentina

CIPADI

Godoy Cruz, 5501, Argentina

Centro Medico Dr. Javier Marino

Haedo, B1706CZA, Argentina

Hospital Italiano de La Plata

La Plata, B1900AXI, Argentina

Unidad de Cardiologia Clinica

Mar del Plata, B7600FEN, Argentina

Hospital Privado de Comunidad

Mar del Plata, B7602CBM, Argentina

Hospital Central de Mendoza, Mendoza

Mendoza, 5500, Argentina

Hospital San Martin

Paraná, E3100BBJ, Argentina

Sanatorio San Martin S.A., Venado Tuerto

Pellegrini, S2600KUE, Argentina

CER Instituto Médico

Quilmes, B1878DVB, Argentina

Instituto de Investigaciones Clínicas de Quilmes

Quilmes, B1878GEG, Argentina

Instituto de Investigaciones Clinicas de Rosario

Rosario, 2000, Argentina

Instituto Medico de la Fundacion Estudios Clinicos, Rosario

Rosario, 2000, Argentina

Instituto Medico Fundación Grupo Colaborativo Rosario

Rosario, 2000, Argentina

Sanatorio Británico

Rosario, 2000, Argentina

Sanatorio Norte

Rosario, 2000, Argentina

Instituto de Hematologia y Medicina Clinica Ruben Davoli

Rosario, CP2000, Argentina

Sanatorio Delta

Rosario, S2000BIF, Argentina

Centro Medico CIR

Rosario, S2000DEJ, Argentina

CEDyN

Rosario, S2000DNM, Argentina

Instituto CAICI

Rosario, S2000PBJ, Argentina

Instituto Medico CENICLAR-C de Investigaciones Clinicas

Rosario, S2000QID, Argentina

Centro Cardiovascular Salta

Salta, 4406, Argentina

CORDIS S.A., Salta

Salta, A4400ANW, Argentina

Prevencion Cardiovascular Salta, Salta

Salta, A4400CRC, Argentina

Investigaciones Clinicas Tucuman

San Miguel de Tucumán, T4000ICL, Argentina

CCBR Tucuman

San Miguel de Tucumán, T4000, Argentina

Instituto de Investigaciones Clinicas San Nicolas

San Nicolás, B2900DMH, Argentina

Centro Medico Luquez

San Vicente, X5006CBI, Argentina

Hospital "Dr. José Maria Cullen "

Santa Fe, S3000EOZ, Argentina

Centro de Investigaciones Clínicas del Litoral

Santa Fe, S3000FWO, Argentina

Clinica Privada Fusavim SRL

Villa María, X5900JKA, Argentina

Instituto de Investigaciones Clínicas Zárate

Zárate, 2800, Argentina

Hospital Universitário João de Barros Barreto

Belém, 66073-000, Brazil

Hospital Felício Rocho

Belo Horizonte, 30110-060, Brazil

Hospital Lifecenter

Belo Horizonte, 30110-921, Brazil

Hospital Vera Cruz

Belo Horizonte, 30140-062, Brazil

Hospital Angelina Caron

Campina Grande do Sul, 83430-000, Brazil

HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas

Campinas, 13060-904, Brazil

CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas

Campinas, 13087-567, Brazil

Hospital Universitário

Canoas, 92425-900, Brazil

Universidade de Caxias do Sul - IPCEM - Inst. de Pesq.clilni

Caxias do Sul, 95070-560, Brazil

Hospital de Caridade Santa Casa de Misericordia de Curitiba

Curitiba, 80010-030, Brazil

HC UFPR

Curitiba, 80030-110, Brazil

Cruz Vermelha Brasileira - Filial do Estado do Paraná

Curitiba, 80030-480, Brazil

Centro de Estudos em Diabetes e Hipertensão

Fortaleza, 60115-282, Brazil

Centro de Pesquisas em Diabetes e Doenças

Fortaleza, 60430-350, Brazil

ICE-HUWC - Instituto Cearense de Endocrinologia

Fortaleza, 60430-370, Brazil

Via Médica

Goiânia, 74223-130, Brazil

Hospital Bruno Born

Lajeado, 95900-000, Brazil

ICM - Instituto do Coração de Marília

Marília, 17515-000, Brazil

Hospital São Vicente de Paulo

Passo Fundo, 99010-080, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre, 90035-074, Brazil

Centro de Pesquisas em Diabetes

Porto Alegre, 90035-170, Brazil

Instituto de Cardiologia Rio Grande do Sul

Porto Alegre, 90620-001, Brazil

Centro de Pesquisas Médicas Básica e Clínica Ltda

Recife, 52020-010, Brazil

CCBR - Rio de Janeiro - BR

Rio de Janeiro, 22271-100, Brazil

Centro de Pesquisa Clínica Santa Maria

Santa Maria, 97015-530, Brazil

CCBR Brasil - São Paulo

Santo André, 09190510, Brazil

Instituto Domingo Braile

São José do Rio Preto, 15015-750, Brazil

Fundacao Faculdade Regional de Medicina, Sao Jose

São José do Rio Preto, 15090-000, Brazil

Cpquali Pesquisa Clinica Ltda

São Paulo, 01228-000, Brazil

Centro de Pesquisa Clinica - CPCLIN

São Paulo, 01244-030, Brazil

Hospital Alemao Oswaldo Cruz

São Paulo, 01323-903, Brazil

FGM Clínica Paulista de Doenças Cardiovasculares LTDA

São Paulo, 01327-010, Brazil

Hospital Sao Paulo - UNIFESP

São Paulo, 04022-001, Brazil

Hospital do Servidor Público Estadual

São Paulo, 04039-901, Brazil

Dr. Consulta

São Paulo, 04254-020, Brazil

Hospital das Clinicas da FMUSP

São Paulo, 05403-000, Brazil

Incor - Instituto do Coração - HCFMUSP

São Paulo, 05403-000, Brazil

IMC - Instituto de Moléstias Cardiovasculares Tatuí

Tatuí, 18270-170, Brazil

ICT - Instituto do Coração do Triângulo

Uberlândia, 38400-368, Brazil

MHAT - Blagoevgrad, EOOD

Blagoevgrad, 2700, Bulgaria

MHAT "Yuliya Vrevska" EOOD, Byala

Byala, 7100, Bulgaria

MHAT "Dr.Stambolski", Cardiology&Intensiv Care Dept,Kazanlak

Kazanlak, 6100, Bulgaria

UMHAT "Kaspela", EOOD, Plovdiv

Plovdiv, 4002, Bulgaria

DCC 1 - Ruse, EOOD

Rousse, 7002, Bulgaria

Fifth MHAT - Sofia EAD, Sofia

Sofia, 1233, Bulgaria

MHAT Lyulin

Sofia, 1336, Bulgaria

MHAT 'Tokuda Hospital Sofia', EAD

Sofia, 1407, Bulgaria

USHATE Hospital 'Academy Ivan Penchev', Sofia

Sofia, 1431, Bulgaria

DCC "Equita" EOOD

Varna, 9000, Bulgaria

ALTA Clinical Research Inc.

Edmonton, Alberta T5A 4L8, Canada

The Bailey Clinic

Red Deer, Alberta T4N 6V7, Canada

Dr. Ronald Collette

Burnaby, British Columbia V5G 1T4, Canada

The Medical Arts Health Research Group

Penticton, British Columbia V2A5G8, Canada

LMC Clinical Research dba Manna Research Inc. Vancouver

Vancouver, British Columbia V6J 1S3, Canada

Fraser Clinical Trials Inc.

Victoria, British Columbia V8R 4R2, Canada

Discovery Clinical Services Ltd.

Victoria, British Columbia V8T 5G4, Canada

CookMed Research

Victoria, British Columbia V8V 4A1, Canada

Winnipeg Regional Health Authority, Winnipeg

Winnipeg, Manitoba R3E 3P4, Canada

True North Clinical Research Halifax, Inc.

Halifax, Nova Scotia B3S 1M7, Canada

LMC Endocrinology Centres (Barrie) Ltd.

Barrie, Ontario L4N 7L3, Canada

JBN Medical Diagnostic Services Inc.

Burlington, Ontario L7M 4Y1, Canada

LMC Endocrinology Centres (Etobicoke) Ltd.

Etobicoke, Ontario M9R 4E1, Canada

Medicor Research

Greater Sudbury, Ontario P3E 1H5, Canada

Sudbury Cardiac Research

Greater Sudbury, Ontario P3E 2N8, Canada

Dr. R. Labonte Prof. Med. Corp

Greater Sudbury, Ontario P3E 3B8, Canada

LMC Endocrinology Centres (Markham) Ltd.

Markham, Ontario L6B 0P9, Canada

SKDS Research Incorporated

Newmarket, Ontario L3Y 5G8, Canada

ViaCar Recherche Clinique Inc

Brossard, Quebec J4Z 2K9, Canada

Hopital Charles - LeMoyne

Greenfield Park, Quebec J4V 2G9, Canada

Centre De Recherche Clinique

Laval, Quebec H7T 2P5, Canada

Recherche Invascor Inc.

Longueuil, Quebec J4N 1C2, Canada

Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec H2X 0A9, Canada

McGill University Health Centre (MUHC)

Montreal, Quebec H4A 3J1, Canada

St Jerome Medical Research Inc.

Saint-Jérôme, Quebec J7Z 5T3, Canada

LMC Endocrinology Centres (Montreal)

Saint-Laurent, Quebec H4T 1Z9, Canada

Recherche Clinique Sigma Inc.

Québec, G1G 3Y8, Canada

Clinique des maladies Lipidiques de Quebec

Québec, G1V 4M6, Canada

Hospital Regional de Punta Arenas Dr. Lautaro Navarro Avaria

Punta Arenas, 6200000, Chile

Hospital El Pino

Santiago, 0, Chile

Sociedad Medica Cardiologica El Llano

Santiago, 0, Chile

Hospital Militar de Santiago

Santiago, 7850000, Chile

Hospital Sotero del Rio

Santiago, 8150000, Chile

CeCim - Centro de Estudios Clinicos e Investigacion Medica

Santiago, 8331143, Chile

Hospital Padre Alberto Hurtado

Santiago, 8880465, Chile

Hospital Base Valdivia

Valdivia, 5090000, Chile

Hospital Naval Almirante Nef

Viña del Mar, 2520000, Chile

Beijing Jishuitan Hospital

Beijing, 100035, China

Third Affiliated Hospital of Guangzhou Medical University

Guangzhou, 510150, China

Zhejiang University School of Medicine SIR RUN RUN SHAW Hospital

Hangzhou, 310016, China

Center Hospital of Jinan

Jinan, 250013, China

People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, 530021, China

Tongji Hospital, Tongji University

Shanghai, 200065, China

First Affiliated Hospital of Xi'an JiaoTong University

Xi'an, 710061, China

General Hospital of Ningxia Medical University

Yinchuan, 750004, China

CEQUIN

Armenia, 55860, Colombia

Corazon IPS S.A.S.

Barranquilla, 0000, Colombia

Clínica de la Costa Ltda.

Barranquilla, 0, Colombia

IPS Centro Cientifico Asistencia

Barranquilla, 80020, Colombia

Centro de Atencion e Investigacion Medica S.A. - CAIMED

Bogotá, 0, Colombia

CAFESALUD Medicina Prepagada S.A.

Bogotá, 110221, Colombia

Dexa Diabetes Servicios Médicos Ltda

Bogotá, 110221, Colombia

Solano y Terront Servicios Médicos Ltda.

Bogotá, 110221, Colombia

Fundacion Reina Isabel

Cali, 0, Colombia

IPS Centro Medico Julián Coronel S.A.

Cali, 0, Colombia

Fundación Centro de Investigaciones Biomédicas Riescard

Espinal, 0, Colombia

Centro de Investigacion Clínica Avanzada

Medellín, 0, Colombia

Fundacion Centro de Investigacion Clinica CIC, Medellin

Medellín, 50021, Colombia

Fundacion Centro de Obesidad y Metabolismo - COMETA

Pasto, 52002, Colombia

Healthy Medical CenterS.A.S, Zipaquirá

Zipaquirá, 0, Colombia

General Hospital Karlovac

Karlovac, 47000, Croatia

Hospital for Medical Rehabilitation, Krapinske Toplice

Krapinske Toplice, 49217, Croatia

General Hospital Slavonski Brod

Slavonski Brod, 35000, Croatia

General Hospital Varazdin

Varaždin, 42000, Croatia

General Hosp. Zadar, Dept. of Internal Medicine-Pulmonology

Zadar, 23000, Croatia

Clinical Hospital Sveti Duh

Zagreb, 10000, Croatia

University hospital center Zagreb

Zagreb, 10000, Croatia

Fakultni nemocnice u sv. Anny v Brne

Brno, 656 91, Czechia

Fakultni nemocnice u sv. Anny v Brne

Brno, 65691, Czechia

Revmatologie Bruntal, s.r.o.

Bruntál, 792 01, Czechia

Poliklinika Chocen, a.s.

Choceň, 56501, Czechia

Aesculap Ambulance Sro

Dolní Břežany, 252 41, Czechia

OKELI s.r.o.

Hodonín, 695 01, Czechia

Nemocnice Jindrichuv Hradec a.s.

Jindřichův Hradec, 377 01, Czechia

Regional Hospital Liberec

Liberec, 460 63, Czechia

InterKardioML s.r.o.

Mariánské Lázně, 353 01, Czechia

Interna a diabetologicka ordinace s.r.o.

Náchod, 547 01, Czechia

PreventaMed, s.r.o.

Olomouc, 77900, Czechia

Univ. Hospital Kralovske Vinohrady

Prague, 100 34, Czechia

Vseobecna fakultni nemocnice V Praze

Prague, 128 08, Czechia

ResTrial s.r.o.

Prague, 181 00, Czechia

Thomayer Hospital

Praha 4 - Krc, 140 59, Czechia

Hospital Slany, Internal Department

Slaný, 274 01, Czechia

Krajska zdravotni, a.s. - Nemocnice Teplice, o.z.

Teplice, 41501, Czechia

Studienzentrum Aschaffenburg

Aschaffenburg, 63739, Germany

Zentrum für klinische Forschung Dr. med. Irma Schöll & Kollegen

Bad Homburg, 61348, Germany

Universitätsklinikum Carl Gustav Carus Dresden

Dresden, 1307, Germany

ClinPhenomics GmbH & Co KG, Frankfurt

Frankfurt, 60594, Germany

IKF Pneumologie GmbH & Co. KG

Frankfurt am Main, 60596, Germany

Diabetologische Schwerpunktpraxis, Hohenmölsen

Hohenmölsen, 6679, Germany

EUGASTRO GmbH, Leipzig

Leipzig, 4103, Germany

Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut, Leipzig

Leipzig, 4249, Germany

Lausmed Kft. Outpatient Unit of Internal Medicine

Baja, 6500, Hungary

Dr. Kenessey Albert Kórház-Rendelõintézet, Balassagyarmat

Balassagyarmat, 2660, Hungary

DRC Gyogyszervizsgalo Kozpont Kft., Balatonfured

Balatonfüred, 8230, Hungary

Clinexpert Kft.

Budapest, 1033, Hungary

Obudai Egeszsegugyi Centrum

Budapest, 1036, Hungary

QUALICLINIC Kft

Budapest, 1036, Hungary

Semmelweis Egyetem, Budapest

Budapest, 1083, Hungary

Semmelweis Egyetem, Budapest

Budapest, 1088, Hungary

Semmelweis Egyetem, Budapest

Budapest, 1125, Hungary

University Debrecen Hospital

Debrecen, 4032, Hungary

Markhot Ferenc Hospital, Eger

Eger, 3300, Hungary

Csongrad Megyei Eu. Ellato Kozp. Hodmezovasarhely-Mako

Hódmezővásárhely, 6800, Hungary

Somogy Megyei Kaposi Mor Oktato Korhaz, Kaposvar

Kaposvár, 7400, Hungary

Selye Janos Hospital Komarom

Komárom, 2900, Hungary

Ermellek Egeszsegcentrum

Létavértes, 4281, Hungary

Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz

Miskolc, 3526, Hungary

Pecsi Tudomanyegyetem

Pécs, 7624, Hungary

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klin. Kozpont

Szeged, 6725, Hungary

Zala Megyei Szent Rafael Korhaz

Zalaegerszeg, 8900, Hungary

Haemek Medical Center

Afula, 18101, Israel

Bnei Zion Medical Center, Haifa

Haifa, 31048, Israel

Rambam Medical Center

Haifa, 3109601, Israel

Herzliya Medical Center

Herzliya, 4685107, Israel

Wolfson Medical Center

Holon, 58100, Israel

Hadassah Medical Center, Ein-Karem

Jerusalem, 9112001, Israel

Meir Medical Center

Kfar Saba, 4428164, Israel

Galilee Medical Center

Nahariya, 2210001, Israel

Ziv Medical Center

Safed, 13100, Israel

Sourasky Medical Center

Tel Aviv, 6423906, Israel

Daishinkai Medical Corporation Ookuma Hospital

Aichi, Nagoya, 462-0825, Japan

Seikeikai New Tokyo Heart Clinic

Chiba, Matsudo, 271-0077, Japan

Saiseikai Matsuyama Hospital

Ehime, Matsuyama, 791-8026, Japan

Aso Co.,Ltd Iizuka Hospital

Fukuoka, Iizuka, 820-8505, Japan

Kitakyushubyoin Kitakyushu General Hospital

Fukuoka, Kitakyushu, 800-0295, Japan

The Veritas Hospital

Hyogo, Kawanishi, 666-0125, Japan

Ibaraki Seinan Medical Center Hospital

Ibaraki, Sashima-gun, 306-0433, Japan

Kokan Clinic

Kanagawa, Kawasaki, 210-0852, Japan

Nagano Red Cross Hospital

Nagano, Nagano, 380-8582, Japan

Josuikai Olive Takamatsu Medical Clinic

Takamatsu, 760-0076, Japan

Hospital Sultanah Bahiyah

Alor Star, 5460, Malaysia

Hospital Tengku Ampuan Rahimah

Klang, 41200, Malaysia

University Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia

Hospital Tengku Ampuan Afzan

Kuantan, 25100, Malaysia

Monash University(Sunway Campus)

Petaling Jaya, 46150, Malaysia

Hospital Pulau Pinang

Pulau Pinang, 10450, Malaysia

Universiti Putra Malaysia

Serdang, 43400, Malaysia

Hospital Seri Manjung

Seri Manjung, 32040, Malaysia

Hospital Taiping

Taiping, 34000, Malaysia

Klinik Kesihatan Tampin

Tampin, 73009, Malaysia

Investigación en Salud y Metabolismo S.C.

Chihuahua City, 31237, Mexico

Phylasis Clinicas Research S de RL de CV

Cuautitlán Izcalli, 54769, Mexico

Centro para el Desarrollo de la Medicina y de Asist Med Espe

Culiacán, CP80020, Mexico

Centro de Investigacion Biomedica y Farmaceutica, S.C.

Distrito Federal, 03100, Mexico

Servicios Medicos de la Pena SC

Guadalajara, 44690, Mexico

Medical Care & Research SA de CV

Mérida, 97070, Mexico

Sociedad de Cirugia Vascular Plastica Reconstructiva

Mérida, 97129, Mexico

Phytomedicamenta S.A. de C.V.

México, 03100, Mexico

Comite Mexicano Para la Prevencion de Osteoporosis AC

México, 06100, Mexico

Centro de Atención e Investigación en Factores de Riesgo

México, 06700, Mexico

Clinstile S.A. de C.V.

México, 06700, Mexico

Ultimate Medica SA de CV

México, 11850, Mexico

Health Pharma Professional Research S.A. de C.V.

México, 3810, Mexico

Centro de Estudios Clinicos y Especialidades Medicas, S.C.

Monterrey, 64620, Mexico

AVIX Investigación Clínica S.C

Monterrey, 64710, Mexico

Global Trial Research Center S.A. de C.V.

Monterrey, 64718, Mexico

Centro de Investigacion Clinica Chapultepec S. A. de C. V.

Morelia, 58260, Mexico

Centro de Estudios Clínicos de Queretaro S.C., CECLIQ

Querétaro, 76000, Mexico

Centro de Investigacion Cardiovascular y Metabolica

Tijuana, 22500, Mexico

Centro de Investigación Médica de Ocidente, S.C.

Zapopan, 45116, Mexico

Hospital Dr Angel Leano

Zapopan, 45200, Mexico

Rijnstate Hospital

Arnhem, 6815 AD, Netherlands

Albert SchweitzerZiekenhuis

Dordrecht, 3318 AT, Netherlands

Universitair Medisch Centrum Groningen

Groningen, 9713 GZ, Netherlands

Martini Ziekenhuis

Groningen, 9728 NT, Netherlands

Bethesda Cardiology Group, Hoogeveen

Hoogeveen, 7909 AA, Netherlands

Maastricht Universitair Medisch Centrum

Maastricht, 6229 HX, Netherlands

Rotterdam Research Institute

Rotterdam, 3039 BD, Netherlands

Universitair Medisch Centrum Utrecht

Utrecht, 3584 CX, Netherlands

TweeSteden Ziekenhuis

Waalwijk, 5141 BM, Netherlands

Gelre Ziekenhuis Zutphen

Zutphen, 7207 BA, Netherlands

B_Serwis Popenda Sp.Jawna

Chorzów, 41-500, Poland

Poradnia Kardiologiczna Jaroslaw Jurowiecki

Gdansk, 80-286, Poland

University Clinical Center, Gdansk

Gdansk, 80-952, Poland

Indywidualna Specjalistyczna Praktyka Lekarska

Gdynia, 81-157, Poland

MCBK Iwona Czajkowska Anna Podrazka- Szczepaniak S.C.

Grodzisk Mazowiecki, 05-825, Poland

Centrum Medyczne Pratia Katowice II

Katowice, 40-084, Poland

Polimedica Centrum Bada?, Profilaktyki I Leczenia

Kielce, 25-364, Poland

NZOZ Centrum Medyczne ProMiMed Sp. z o.o., Sp.k., Krakow

Krakow, 31-637, Poland

Centrum Terapii Wspolczesnej J.M.

Lodz, 90-242, Poland

CCBR - Lodz - PL, Lodz

Lodz, 90-368, Poland

Individual Specialized Practice

Lodz, 94-255, Poland

Centrum Medyczne "Luxmed" Sp. z o.o.

Lublin, 20-109, Poland

KO-MED Centra Kliniczne Lublin II

Lublin, 20-362, Poland

NZOZ Specialized Ambulance "MEDICA"

Lublin, 20-538, Poland

RCMed- Regionalne Centrum Medyczne

Nowy Duninów, 09-505, Poland

Medicome Sp. z o.o.

Oświęcim, 32-600, Poland

Prywatny Gabinet Lekarski Lech Lazuka

Parczew, 21-200, Poland

Clin.Hosp.Med.Univ.Marcinkowski in Poznan

Poznan, 60-569, Poland

Praktyka Lekarska Ewa Krzyzagorska

Poznan, 61-655, Poland

KOMED Marek Konieczny

Puławy, 24-100, Poland

Indywidualna Specjalistyczna Praktyka Lekarska Dr N Med Andrzej Wittek

Ruda Śląska, 41-709, Poland

Centrum Medyczne Medyk

Rzeszów, 35-055, Poland

RCMed- Regionalne Centrum Medyczne

Sochaczew, 96-500, Poland

KO-MED Centra Kliniczne Staszow

Staszów, 28-200, Poland

NSZOZ Medicus

Środa Wielkopolska, 63-000, Poland

Lecznice Citomed Sp. z o.o.

Torun, 87-100, Poland

NZOZ Nasz Lekarz

Torun, 87-100, Poland

NBR Polska

Warsaw, 00-465, Poland

CCBR/Somed - Warszaw - PL

Warsaw, 04-730, Poland

Regionalna Poradnia Diabetoloiczna Zytkiewicz-Jaruga

Wroclaw, 50-127, Poland

KO-MED Centra Kliniczne Zamosc

Zamość, 22-400, Poland

Polimedica Centrum Bada?, Profilaktyki I Leczenia

Zgierz, 95-100, Poland

Hospital de Braga-Escala Braga

Braga, 4710-243, Portugal

CHUC - Centro Hospitalar e Universitário de Coimbra, EPE

Coimbra, 3000-075, Portugal

APDP - Associação Protectora dos Diabéticos de Portugal

Lisbon, 1250-203, Portugal

CHLO, EPE - Hospital S. Francisco Xavier

Lisbon, 1449-005, Portugal

Hospital da Luz

Lisbon, 1500-650, Portugal

Hospital CUF Porto

Porto, 4100-180, Portugal

Centro Hospitalar de Vila Nova de Gaia

V. N. Gaia, 4434-502, Portugal

SC Diana Barbonta SRL, Alba Iulia

Alba Iulia, 510053, Romania

Spitalul Universitar de Urgenta, Bucuresti

Bucharest, 010825, Romania

I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central

Bucharest, 011234, Romania

I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central

Bucharest, 020475, Romania

CMI Dr. Stolea T. Violeta

Bucharest, 061072, Romania

Clinica Medicala Data Plus SRL

Bucharest, 10192, Romania

I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul "I.L. Caragiale"

Bucharest, 20045, Romania

S.C Centrul Medical "Sanatatea Ta" S.R.L

Bucharest, 20614, Romania

S.C. Policlinica CCBR SRL, Bucuresti

Bucharest, 30463, Romania

Medcon SRL

Buzău, 120203, Romania

Spitalul Clinic Judetean de Urgenta ¿Sf. Apostol Andrei¿

Galati, 800578, Romania

Spitalul Clinic, Iasi

Iași, 700503, Romania

Consultmed SRL, Iasi

Iași, 700547, Romania

SC Diaconu-Sotropa Michaela, Cabinet de Diabet

Iași, 700613, Romania

S.C Grandmed S.R.L, Oradea

Oradea, 410159, Romania

Pelican Impex SRL, Cabinet Nr. 15

Oradea, 410469, Romania

S.C Anamed S.R.L

Oradea, 410491, Romania

S.C. Diabmed Dr. Popescu Alexandrina S.R.L

Ploieşti, 100163, Romania

Gensan SRL

Sibiu, 550371, Romania

Mediab SRL

Târgu Mureş, 540142, Romania

Centrul Medical Dr Negrisanu SRL

Timișoara, 300456, Romania

SBEI HPE Altay State Medical University of MoH and SD

Barnaul, 656038, Russia

Res.Inst.-Compl.Iss.Cardi.Dis.

Kemerovo, 650002, Russia

NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"

Kemerovo, 650055, Russia

First Moscow State Medical University n.a. I.M. Sechenov

Moscow, 119435, Russia

Moscow 1st State Med.Univ.n.a.I.M.Sechenov

Moscow, 119992, Russia

SBEI HPE "Moscow State Medical and Dentistry University

Moscow, 127473, Russia

Moscow State Medical Dentistry University

Moscow, 129301, Russia

SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"

Novosibirsk, 630008, Russia

Novosibirsk Regional Clinical Cardiological Dispansary

Novosibirsk, 630047, Russia

FSBSI "Scientific Research Institute", Novosibirsk

Novosibirsk, 630089, Russia

FSBSI "Scientific and Research Institute of Physiology and Basic Medicine"

Novosibirsk, 630117, Russia

BIH of OR "City Hospital # 2", Omsk

Omsk, 644021, Russia

SBIH of Perm territory " City Clinical Hospital # 2 n.a.

Perm, 614068, Russia

SBI of Ryazan region "Regional Clinical Cardiological Dis.

Ryazan, 390026, Russia

FSBMEI HPE "Military Medical Academy n.a. S.M. Kirov"

Saint Petersburg, 194044, Russia

Medical Research Institute LLC, St. Petersburg

Saint Petersburg, 196084, Russia

1stPavlov St.Med.Univ.St.-Petersburg Res.Inst.

Saint Petersburg, 197022, Russia

Federal North-West Medical Research Centre

Saint Petersburg, 197341, Russia

SPb SBHI "City Policlinic #74"

Saint Petersburg, 197762, Russia

SPb SBIH "City Pokrovskaya Hospital"

Saint Petersburg, 199106, Russia

GUZ "City Clinical Hospital #40, 197706 Saint-Petersburg

Sestroretsk, 197706, Russia

FSBI "Research Institute for Cardiology"

Tomsk, 634012, Russia

Cardiology Clinical Research

Alberton, 1449, South Africa

Iatros International

Bloemfontein, 9301, South Africa

Limaro Research

Bloemfontein, 9301, South Africa

Dr JM Engelbrecht Practice

Cape Town, 7129, South Africa

Dr Dawood, Mohamed and Pillay

Cape Town, 7405, South Africa

TREAD Research

Cape Town, 7500, South Africa

Langeberg Clinical Trials

Cape Town, 7570, South Africa

Cape Town Medical Research Centre

Cape Town, 7580, South Africa

Ismail, SM

Cape Town, 7764, South Africa

Groote Schuur Hospital

Cape Town, 7925, South Africa

Latiff, GHVM

Durban, 4001, South Africa

Londisizwe Research Centre, Durban

Durban, 4001, South Africa

Diabetes Care Centre

Johannesburg, 1501, South Africa

Wits Clinical Research Chris Hani Baragwanath Hospital

Johannesburg, 2013, South Africa

WCR CMJAH Clinical Trial Site

Johannesburg, 2193, South Africa

DJW Navorsing

Krugersdorp, 1739, South Africa

Emmed Research

Pretoria, 0002, South Africa

University of Pretoria

Pretoria, 0002, South Africa

Syzygy Clinical Research Services

Pretoria, 0087, South Africa

Into Research

Pretoria, 181, South Africa

Seeber, M

Pretoria, 2, South Africa

Dr M Duki Research and Trial Site, Verulam

Verulam, 4339, South Africa

Clinical Projects Research

Worcester, 6850, South Africa

Hallym University Sacred Heart Hospital

Anyang-si, 431-070, South Korea

Inje University Busan Paik Hospital

Busan, 47392, South Korea

Dong-A University Hospital

Busan, 602-715, South Korea

Pusan National Univ. Hosp

Busan, 602-739, South Korea

Myongji Hospital

Goyang-si, 412-270, South Korea

Gachon University Gil Medical Center

Incheon, 21565, South Korea

The Catholic University of Korea, Seoul St.Mary's Hospital

Seoul, 06591, South Korea

Seoul National University Hospital

Seoul, 110744, South Korea

Asan Medical Center

Seoul, 138736, South Korea

Korea University Anam Hospital

Seoul, 2841, South Korea

Korea University Guro Hospital

Seoul, 8308, South Korea

Wonju Severance Christian Hosp

Wŏnju, 26426, South Korea

Hospital Virgen del Mar

Almería, 04120, Spain

Hospital de la Ribera

Alzira, 46600, Spain

Hospital Germans Trias i Pujol

Badalona, 08916, Spain

Specialist

Barcelona, 08006, Spain

CAP Sarria

Barcelona, 08017, Spain

Hospital Quiron. I.C.U.

Barcelona, 08023, Spain

EBA Centelles

Centelles, 08540, Spain

Fundación Jiménez Díaz

Madrid, 28040, Spain

Hospital Regional Universitario de Málaga

Málaga, 29010, Spain

Hospital General de Segovia

Segovia, 40002, Spain

Hospital Quironsalud Infanta Luisa

Seville, 41010, Spain

Hospital Virgen Macarena

Seville, 41071, Spain

Hospital General Universitario de Valencia

Valencia, 46014, Spain

Hospital Dr. Peset

Valencia, 46017, Spain

Hospital Virgen de las Montañas, Villamartin

Villamartín, 11650, Spain

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan

Kaohsiung Veterans General Hospital

Kaohsiung City, 81362, Taiwan

Far Eastern Memorial Hospital

New Taipei City, 220, Taiwan

China Medical University Hospital

Taichung, 404, Taiwan

NCKUH

Tainan, 704, Taiwan

National Taiwan University Hospital

Taipei, 100, Taiwan

Taipe Veterans General Hospital

Taipei, 11217, Taiwan

Chang-Gung Memorial Hospital, Linkou

Taoyuan County, 333, Taiwan

Chernivtsi Regional Endocrinology Dispensary

Chernivtsi, 58022, Ukraine

Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU

Ivano-Frankivsk, 76008, Ukraine

CI Ivano-Frankivsk Reg Cl Card Center

Ivano-Frankivsk, 76018, Ukraine

L.T. Malaya Institute of Therapy AMS of Ukraine

Kharkiv, 61039, Ukraine

CIPH Prof. O.I. Meshchaninov Kharkiv CCH of A&E

Kharkiv, 61103, Ukraine

CI of Healthcare Kharkiv CCH #8, Kharkiv

Kharkiv, 61176, Ukraine

KCCC of Endocr Dept of General Endocrine Pathology

Kyiv, 01004, Ukraine

City Clinical Hospital No. 1, Kiev

Kyiv, 02091, Ukraine

V.P. Komisarenko Inst. of Endocrinology and Metabolism

Kyiv, 04114, Ukraine

Kjiv City Oleksandrivska Clinical Hospital

Kyiv, 1601, Ukraine

LLC Treatment and Diagnostic Center Adonis Plus, Kyiv

Kyiv, 2002, Ukraine

SI National Scientific Centre of Radiation Medicine of NAMSU

Kyiv, 3115, Ukraine

P.L. Shupyk NMA of PGE Ch of D H for S-ts of NASU

Kyiv, 4050, Ukraine

SI V.P.Komisarenko Institute of Endocrinology and Metabolism

Kyiv, 4114, Ukraine

Lviv Regional Endocrinology Dispensary

Lviv, 79010, Ukraine

M.V. Sklifosovskyi Poltava RCH, Poltava

Poltava, 36011, Ukraine

CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU

Sumy, 40021, Ukraine

CI of TRC Ternopil UH

Ternopli, 46002, Ukraine

Private Small Enterprise Medical Center Pulse

Vinnytsia, 21001, Ukraine

Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy

Vinnytsia, 21010, Ukraine

M.I. Pyrogov VRCH, Vinnytsia

Vinnytsia, 21018, Ukraine

CCH #1 M.I. Pyrogov VNMU Ch of Propaedeutics of IM

Vinnytsia, 21021, Ukraine

CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin

Zaporizhzhya, 69001, Ukraine

University Hospital Monklands

Airdrie, ML6 0JS, United Kingdom

Queen Elizabeth Hospital

Birmingham, B15 2TH, United Kingdom

Bradford on Avon Health Centre

Bradford-on-Avon, BA15 1DQ, United Kingdom

Ashgate Medical Practice

Chesterfield, S40 4AA, United Kingdom

Dumfries and Galloway Royal Infirmary

Dumfries, DG1 4AP, United Kingdom

Ninewells Hospital & Medical School

Dundee, DD1 9SY, United Kingdom

Royal Devon and Exeter Hospital

Exeter, EX2 5DW, United Kingdom

Glasgow Royal Infirmary

Glasgow, G4 0SF, United Kingdom

Leicester General Hospital

Leicester, LE5 4PW, United Kingdom

Barts and The London School of Medicine and Dentistry

London, EC1M 6BQ, United Kingdom

Morriston Hospital

Swansea, SA6 6NL, United Kingdom

Queen Elizabeth II Hospital

Welwyn Garden City, AL7 4HQ, United Kingdom

New Cross Hospital

Wolverhampton, WV10 0QP, United Kingdom