IVF/ICSI Protocols in Poor Responders With Growth Hormone

Which is the Best IVF/ICSI Protocol to be Used in Poor Responders Receiving Growth Hormone as an Adjuvant Treatment ? A Prospective Randomized Study

in this study, we are trying to monitor the effect of the addition of growth hormone on the different down regulation protocols ( long, short, antagonist and microflare). The outcome will be primarily assessed by the clinical pregnancy rates.

Poor responders undergoing IVF/ICSI cycles have emerged as a major problem. the need to find a proper stimulation protocol is a must. in this study we are trying to detect the best stimulation protocol ,in addition to growth hormone ,that can give the highest pregnancy rates in these patients.

Inclusion Criteria:

ESHRE consensus 2011,At least two of the following three features must be present:

• Advanced maternal age (≥40 years) or any other risk factor for POR;
• A previous POR (≤3 oocytes with a conventional stimulation protocol);
• An abnormal ovarian reserve test (i.e. AFC < 5-7 follicles or AMH < 0.5 -1.1 ng/ml).

Exclusion Criteria:

• female patients with causes of infertility other than poor ovarian reserve
• females suffering from congenital or acquired uterine anomalies
• females with focal uterine lesions
• females who had previous ovarian surgeries
• females with history of previous exposure to radiotherapy , or chemotherapy
• females refusing to get enrolled in the study