Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.

Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.

The purpose of this randomized clinical trial is to evaluate the effect of acute arterial hypertension maintained during surgery on morphine's requirements in patients undergoing laparoscopic cholecystectomy

The high arterial blood pressure has been correlated with an increase in pain threshold in animal and humans. One of the explanations to this phenomenon is a baroreceptor activity and vasopressin release at the level of spinal cord dorsal horn and hypothalamus.

As far as we know, there is only one study about the effect of chronic hypertension on postoperative pain and none with acute hypertension. We therefore decided to conduct a randomized controlled trial to evaluate the effect of acute hypertension on postoperative morphine's requirements.

Inclusion Criteria:

• American Society of Anesthesiology patient classification status(ASA) I-II
• Between 20 and 60 years of age
• Programed for elective laparoscopic cholecystectomy

Exclusion Criteria:

• History of arterial hypertension
• Baseline blood pressure over 139/89
• Use of opioids and any analgesic drug during the last 24 hours before surgery
• Chronic use of nonsteroidal antiinflammatory
• BMI > 34.9
• History of drug or alcohol abuse
• Use of medications that interfere in the central nervous system
• Adverse reactions to the drugs used in the study
• Pregnancy