Faecal Microbiota Transplantation in Ulcerative Colitis

Faecal Microbiota Transplantation for Chronic Active Ulcerative Colitis - A Randomised Double Blind Controlled Study of Efficacy & Safety

The purpose of this study is to determine whether fecal microbiota transplantation (FMT) is safe and efficacious in the treatment of chronic active ulcerative colitis (UC) by conducting a randomised controlled trial

This study involves the assessment of the safety and efficacy of FMT in the treatment and induction of remission for patients with mild to moderate ulcerative colitis. It is a double blind study with patients randomised in a 1:1 manner to either active or placebo therapy

Inclusion Criteria:

• Ulcerative colitis >3 months duration
• Active mild-moderate ulcerative colitis (Mayo 4-10)
• Ulcerative colitis of any extent except isolated proctitis < 5cm
• Live within driving distance of clinical site (to attend multiple study visits)

Exclusion Criteria:

• Pregnancy
• Active gastrointestinal infection
• Other gastrointestinal disease / comorbidities
• Prior colonic surgery
• Recent antibiotic or probiotic use
• Prednisone > 20mg
• Monoclonal antibody immunosuppressive therapy