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| ID | Type | Description | Link |
|---|---|---|---|
| 292037 | Other Grant/Funding Number | Isfahan University of Medical Sciences | |
| IRCT2013042713140N1 | Registry Identifier | Iranian Registry of clinical trials |
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| Name | Class |
|---|---|
| Isfahan University of Medical Sciences | OTHER |
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In some cases, impacted wisdom teeth should be extracted. Surgical extraction of these impacted third molars may provide special complication as pain, swelling, and trismus. In previous studies, some techniques as sutureless flap closure, modified flap designing, antibiotic usage, and injection of corticosteroids were presented. These methods are reducing post operative complications to moderate level. In this study, pain, swelling, trismus, general patients' satisfaction, and associated quality of life after the surgical removal of third mandibular impacted molars will be compared while injection of dexamethasone (8mg) does not need excessive time, effort, and equipments and it will be injected in numbness area into medial pterygoid muscle and pterygomandibular space to current corticosteroid injecting non-corticosteroid methods. To achieve this aim, 75 non pregnant participants have single impacted mandibular third molar in healthy and without pericoronitis manner, after provision of written informed consent will be entered to the study. During the study, unwilling participants to continue the study and those with abnormality of wound healing process will be excluded. The included participants will be assigned into three 25-people groups. The surgeries were done by 3 same instructed experienced oral and maxillofacial residents. After the surgery pain, swelling, trismus, general patients' satisfaction, and associated quality of life were evaluated using interview of questionnaire in 48 hour, 96 hour, and one week period of time. The comparison was done between these three groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexamethazone IO | Active Comparator | For the case group, after the inferior alveolar block injection and before starting the surgery, single dose of dexamethasone (8mg) will injected into medial pterygoid and pterygomandibular space |
|
| Dexamethasone IM | Active Comparator | For the case group, after the inferior alveolar block injection and before starting the surgery, single dose of dexamethasone (8mg) will injected into medial pterygoid and pterygomandibular space |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione | Drug | single dose of dexamethasone (8mg) will injected |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Pain | Visual analogue scale of pain- Number of required analgesics tablets | 48 hours and one week after intervention |
| Changes in Swelling | Questionnaire and VAS | 48 hours and one week after intervention |
| Changes in Trismus | Questionnaire | 48 hours and one week after intervention |
| Changes in General patients' satisfaction | Visual analogue scale for satisfaction | 48 hours and one week after intervention |
| Changes in Quality of life | Questionnaire | 96 hours and one week after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Trismus | Questionnaire about Maximum mouth opening- Patients complaint | one week period after the surgery |
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Inclusion Criteria:
Exclusion Criteria:
-Unwilling participants to continue the study and those with abnormality of wound healing process
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mohammadjavad Shirani, Dr | Contact | 00989356039479 | javaad.sh_f@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Bijan Movahedian, Oral and maxillofacial surgeon | Department of oral and maxillofacial surgery, Faculty of Dentistry, Isfahan University of Medical Sciences | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of oral and maxillofacial surgery, Faculty of Dentistry, Isfahan University of Medical Sciences | Recruiting | Isfahan | Isfahan | 81745-319 | Iran |
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| ID | Term |
|---|---|
| D004487 | Edema |
| D010146 | Pain |
| D014313 | Trismus |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009461 | Neurologic Manifestations |
| D013035 | Spasm |
| D020879 | Neuromuscular Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| C480824 | 21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione |
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