Impact of Probiotics in Modulation of Intestinal Microbiota

Impact of Probiotics in Modulation of Intestinal Microbiota of Patients Undergoing a Resection Colonic

The investigators would study about impact of the administration of probiotics in the intestinal mucosa of patients undergoing resection colic, by evaluating cytokine profile by quantitative real time PCR. The investigators believe that patients who use probiotic preoperative would provide cytokine profile less inflammatory than those of the control group.

Samples of colorectal cancer-free mucosa derived from patients who underwent surgical resection were investigated. Quantitative real-time polymerase chain reaction (RT-qPCR) was used to determine expression levels of the following genes: IL10, IL1B, IL23A, TNF, IL12B, INFG, IL17A.

Inclusion Criteria:

• if he or she were older than 18 years
• intended to undergo elective CRC resection at UFMG Hospital

Exclusion Criteria:

• Patients were excluded if they were not able to receive the probiotics seven days before the operation
• if colon resection was not performed due to changes in operation strategy, or if they discontinued probiotic use on their own or
• if they removed their consent.