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| ID | Type | Description | Link |
|---|---|---|---|
| UMIN000010843 | Registry Identifier | UMIN Clinical Trials Registry (UMIN-CTR) |
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| Name | Class |
|---|---|
| Keio University | OTHER |
| Jikei University School of Medicine | OTHER |
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The aim of this study is to assess efficacy of the screening with concurrent liquid-based cytology and HPV DNA testing for the primary cervical cancer screening over 7 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LBC | Active Comparator | Cervical cancer screening by using liquid based cytology as a standard screening modality |
|
| LBC plus HPV DNA testing | Experimental | Cervical cancer screening by using liquid based cytology plus HPV DNA testing as an experimentally screening modality |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LBC | Other | Cervical cancer screening by using liquid based cytology as a standard screening modality |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of cervical intraepithelial neoplasia(CIN)3 or worse during the whole period | 6 years |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of CIN3 or worse at baseline, and two years, four years, and six years post baseline | 2 years, 4 years, 6 years | |
| The incidence of CIN2 or worse at baseline, and two years, four years, and six years post baseline | 2 years, 4 years, 6 years |
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Inclusion Criteria:
Exclusion Criteria:
Women who
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Medicine, Keio University | Shinjuku | Tokyo | 160-8582 | Japan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28818742 | Derived | Morisada T, Teramoto K, Takano H, Sakamoto I, Nishio H, Iwata T, Hashi A, Katoh R, Okamoto A, Sasaki H, Nakatani E, Teramukai S, Aoki D. CITRUS, cervical cancer screening trial by randomization of HPV testing intervention for upcoming screening: Design, methods and baseline data of 18,471 women. Cancer Epidemiol. 2017 Oct;50(Pt A):60-67. doi: 10.1016/j.canep.2017.07.017. Epub 2017 Aug 16. |
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| ID | Term |
|---|---|
| D002583 | Uterine Cervical Neoplasms |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| C085467 | AKAP13 protein, human |
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| LBC plus HPV DNA testing | Other | Cervical cancer screening by using liquid based cytology plus HPV DNA testing as an experimentally screening modality |
|
| The incidence of CIN1 or worse at baseline, and two years, four years, and six years post baseline | 2 years, 4 years, 6 years |
| The incidence of invasive cancer at baseline, and two years, four years, and six years post baseline | 2 years, 4 years, 6 years |
| The number of cervical cytology performance | 6 years |
| The number of colposcopy and biopsy performance | 6 years |
| D009369 |
| Neoplasms |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |