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Bovine amniotic membrane may show better efficacy than hydrocolloid dressing.
Bovine amniotic membrane as a biological dressing can be applicable to wound after laser treatments. Comparing with hydrocolloid dressing material, which is the most widely used after laser treatment now, amniotic membrane will show better efficacy. Thus, with amniotic membrane, epithelization time will shorten and redness which is usually left after laser will disappear quickly.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| amniotic membrane dressing | Experimental | We compare the efficacy of amniotic membrane and hydrocolloid in same subjects to avoid confounders. |
|
| Hydrocolloid dressing | Active Comparator | Same subjects received amniotic membrane and hydrocolloid dressing at the same time in different wound. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| laser treatments | Procedure |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Epithelization time | time to complete epithelization after wounding | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Epithelization Scale | Assessment of redness, oozing, swelling | 2 weeks |
| Photometric measurements | spectrophotometer and colorimeter | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dae Hun Suh, PhD | Department of Dermatology, Seoul National University College of Medicine | Study Chair |
| Seonguk Min, Msc | Department of Dermatology, Seoul National University College of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Dermatology, Seoul National University College of Medicine | Seoul | 110-744 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20619656 | Background | Singh R, Chacharkar MP. Dried gamma-irradiated amniotic membrane as dressing in burn wound care. J Tissue Viability. 2011 May;20(2):49-54. doi: 10.1016/j.jtv.2010.06.001. Epub 2010 Jul 8. |
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| ID | Term |
|---|---|
| D053685 | Laser Therapy |
| D001458 | Bandages |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D055011 | Ablation Techniques |
| D013514 | Surgical Procedures, Operative |
| D004864 | Equipment and Supplies |
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| amniotic membrane application | Other |
|
|
| hydrocolloid application | Device |
|
|
| Vancouver scar scale | Vancouver scar scale | 2 weeks |
| Assessment by subjects | pain, itching, inconvenience | 2 weeks |
| measurements of adverse effects | assessments of adverse effects by investigator | 2 weeks |
| histopathologic analysis | changes of the tissue with time | 2 weeks |