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The primary objective of this study is to determine which treatment will be more effective to reduce left ventricular mass in hypertensive patients with left ventricular hypertrophy comparing aliskiren and eplerenone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aliskiren | Active Comparator | Aliskiren group treated with 150-300mg daily aliskiren without diuretics or ACE inhibitors or angiotensin receptor blockers. |
|
| Eplerenone | Active Comparator | Eplerenone group treated with 50-100mg daily eplerenone without diuretics or ACE inhibitors or angiotensin receptor blockers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aliskiren | Drug | Aliskiren: 150 to 300 mg daily for 48 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| reduction of left ventricular hypertrophy measured by magnetic resonance imaging | To compare the 12 month left ventricular mass or left ventricular mass and index measured by magnetic resonance imaging with baseline. | 12 month |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular events | total death, composite cardiovascular events, cardiac function eveluated by UCG,reduction of left ventricular hypertrophy measured by UCG | 12 month |
| Measure | Description | Time Frame |
|---|---|---|
| Biochemical parameters | BNP, PIIINP etc | 12 month |
Inclusion Criteria:
Male or female ≧ 20 years of age Clinical diagnosis of hypertension Patients who are able to provide written informed consent
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Toyoaki Murohara, MD, PhD | Department of Cardiology, Nagoya University Graduate School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiology, Nagoya University Graduate School of Medicine | Recruiting | Nagoya | Aichi-ken | 466-8550 | Japan |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D017379 | Hypertrophy, Left Ventricular |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006332 | Cardiomegaly |
| D006331 | Heart Diseases |
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| ID | Term |
|---|---|
| C446481 | aliskiren |
| D000077545 | Eplerenone |
| ID | Term |
|---|---|
| D007783 | Lactones |
| D009930 | Organic Chemicals |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 |
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| Eplerenone | Drug | 50 to 100 mg daily for 48 weeks |
|
|
| D006984 |
| Hypertrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |