Impact of Opportunistic Salpingectomy on Ovarian Reserve in Patients Undergoing Laparoscopic Hysterectomy

Impact of Opportunistic Salpingectomy on Ovarian Reserve in Patients Undergoing Laparoscopic Hysterectomy: a Multi-center, Randomized Controlled Trial

Recently, many gynecologic oncologists proposed that surgeons should consider opportunistic salpingectomy to prevent ovarian cancer for all patients undergoing hysterectomy for benign disease. However, the safety and the consequences regarding ovarian function after salpingectomy have not yet to be established. Therefore, the aim of this randomized controlled study is compare the ovarian reserve via anti-Müllerian hormone (AMH) between laparoscopic hysterectomy (LH) alone and LH combined with salpingectomy.

Inclusion Criteria:

• women who were planning to undergo laparoscopic hysterectomy for benign uterine diseases
• women aged between 19 and 52 years
• women with regular menstruation (defined as the duration of menstrual cycle between 21 and 45 days)
• women who were appropriated medical status for laparoscopic surgery

Exclusion Criteria:

• any ovarian cysts requiring ovarian surgery
• any suspicious findings of malignant diseases
• history of prior salpingectomy or salpingo-oophorectomy
• pregnant or menopausal status
• preoperative serum anti-Müllerian hormone (AMH) < 0.30 ng/mL
• use of hormonal treatments in the three months before surgery
• any other endocrine disease (such as uncontrolled thyroid dysfunction, hyperprolactinemia, or Cushing syndrome)
• an inability to understand and provide written informed consent.