Efficacy of Antioxidant Therapy Compared With Enalapril in Sickle Nephropathy

A Phase 2 Study of the Efficacy of Antioxidant Therapy Compared With Enalapril in Slowing the Progression of Sickle Nephropathy in Children

The purpose of this study is to determine whether enalapril or antioxidant therapy (N-Acetylcysteine) is effective in reducing microalbuminuria in children with sickle cell disease and and its progression to sickle nephropathy

Inclusion Criteria:

• Homozygous S sickle cell disease
• Diagnosed by newborn screening
• determined to have persistent microalbuminuria
• satisfied criteria for microalbuminuria screening
• parental consent

Exclusion Criteria:

• Asymptomatic bacteriuria on screening urine cultures
• On Hydroxyurea therapy
• Pre-existing complications of SCD which would meet local criteria for HU therapy