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The aim of this study was to assess whether administration of oxytocin intrapartum (Oxt) has any effect on Neonatal Primitive Reflexes (RNP) and if dose dependent. The secondary objective is to assess the effects on exclusive breastfeeding at 3 months
Patients and Methods Prospective case-control study performed in a tertiary hospital. Cases: mother-child dyads in which Oxt had been administered during the birth process (n = 53). Controls: mother-child dyads without Oxt (n = 45). The RNP were recorded with a camcorder in biological nurturing position. An observer blinded to the group and the dose of Oxt codified the RNP (reach/not reached). To assess the type of breastfeeding telephone call was made at 3 months old RN.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Not exposed to oxytocin | Mother-child dyads in which Oxt had not been administered during the birth process |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin | Drug | Comparison of Primitive Newborn Reflexes between those exposed or not to Oxytocin |
|
| Measure | Description | Time Frame |
|---|---|---|
| Expression of Neonatal Primitive Reflexes (RNP) are modified by administration of Oxytocin during delivery. | Neonatal Primitive Reflexes studied were: 1) Endogenous: hand to mouth, extension / flexion of fingers, mouth open, tongue extrusion, arm circular motion, circular motion of the leg, flex foot / hand, 2) Antigravity: raise the head, 3) Motors: turn your head, nod, plantar pressure, Babinski, and 4) Rhythmic: suction, jaw movement and swallowing. An observer, blinded to the study group and the dose administered of Oxytocin, valued recordings, analyzing the state of consciousness at the beginning of the recording as Brazelton scale and form RNP dichotomous coding (achieved / not achieved). | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Oxytocin intrapartum may have adverse influence on exclusive breastfeeding at 3 months. | To assess the type of feeding (exclusive breastfeeding versus other) at different time points (discharge, one month and three months) a telephone call was conducted at 3 months old of the newborn. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Maternity ward of a terciary Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Miguel A MarÃn, MD | Hospital Universitario Puerta de Hierro Majadahonda | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitario Puerta de Hierro-Majadahonda | Madrid | Madrid | 28220 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 1626829 | Background | Carter CS, Williams JR, Witt DM, Insel TR. Oxytocin and social bonding. Ann N Y Acad Sci. 1992 Jun 12;652:204-11. doi: 10.1111/j.1749-6632.1992.tb34356.x. | |
| 12954433 | Background | Carter CS. Developmental consequences of oxytocin. Physiol Behav. 2003 Aug;79(3):383-97. doi: 10.1016/s0031-9384(03)00151-3. |
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| ID | Term |
|---|---|
| D001942 | Breast Feeding |
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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Not provided
| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |