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| ID | Type | Description | Link |
|---|---|---|---|
| 20120570-01H | Other Identifier | Ottawa Hospital Research Ethics Board | |
| AA-HCLM-14-019 | Other Identifier | Comité d'éthique de la recherche du Centre de santé et services sociaux Champlain-Charles LeMoyne |
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| Name | Class |
|---|---|
| The Ottawa Hospital | OTHER |
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Multiple sclerosis is a neurological disease that can affect lung function and cough efficacy. This pilot study will examine whether the lung volume recruitment technique can slow down the decline in lung function and cough.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lung volume recruitment | Experimental | Lung volume recruitment twice daily for 9 months |
|
| Standard care | No Intervention | Standard care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lung volume recruitment | Procedure | Inflation of the lungs to their maximal insufflation capacity by the consecutive delivery, by a manual resuscitator in this study, of volumes of air that are held with a closed glottis |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of decline of FVC (forced vital capacity) | up to 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of decline of peak cough flow | baseline, 2, 4, 6 and 9 months | |
| Change from baseline in FVC at 2, 4, 6 and 9 months | baseline vs 2, 4, 6 and 9 months | |
| Change from baseline in peak cough flow at 2, 4, 6 and 9 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nadim Srour, MD, MSc | Université de Sherbrooke | Study Chair |
| Douglas A McKim, MD | The Ottawa Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Ottawa Hospital | Recruiting | Ottawa | Ontario | K1H 8L6 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23383293 | Background | Srour N, LeBlanc C, King J, McKim DA. Lung volume recruitment in multiple sclerosis. PLoS One. 2013;8(1):e56676. doi: 10.1371/journal.pone.0056676. Epub 2013 Jan 31. |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| baseline vs 2, 4, 6 and 9 months |
| Hôpital Charles-LeMoyne | Recruiting | Greenfield Park | Quebec | J4V2H1 | Canada |
|
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |