Antibiotic Prophylaxis in Laparoscopic Cholecystectomy

Ciprofloxacin, Ampicillin-sulbactam and Placebo Prophylaxis in Laparoscopic Cholecystectomy. A Randomized Controlled Study

The trial aims to assess the value of two-regimen antibiotic prophylaxis versus placebo in elective laparoscopic cholecystectomy.

All patients enrolled will be submitted to laparoscopic cholecystectomy. The primary aim of the trial will be to assess the role of prophylactic i.v. infusion of ampicillin-sulbactam, ciprofloxacin, and placebo to reduce the rate of surgical site infection.

Inclusion Criteria:

• elective laparoscopic cholecystectomy;
• patients suffering from gallbladder stones,chronic cholecystitis, cholesterolosis, or gallbladder polyps.

Exclusion Criteria:

• acute cholecystitis;
• acute cholangitis;
• acute pancreatitis;
• pregnant or lactating women;
• antibiotic allergy;
• antibiotic therapy within 48 hours to 7 days prior to surgery;
• clinically active infection at the moment of surgery;
• evidence of common bile duct stones;
• contraindications for laparoscopic cholecystectomy;
• no other additional procedure;
• indication of obligatory antibiotic prophylaxis because the medical condition was different from biliary disease (immunosuppression, corticoid use, etc).
• patients unable to give informed consent.