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The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.
Thanks to the words generation test, which reflects the cortico-subcortical loop functioning, involved in motivation, we want to evaluate and compare using tools (words generation and behavioral tests) the motivational functioning of gamblers and healthy volunteers that we can then compare to that of Parkinson's patients with and without behavioral hyperdopaminergic disorders which were explored in another study.
The main objective of this study is to evaluate performance during words generation in gamblers and healthy volunteers compare to those of PD patients with and without hyper-dopaminergic behaviors collected during another study.
2 groups of subjects will be recruited for the study: 20 compulsive gamblers and 20 healthy volunteers
Each subject will realize twice each test during 2 sessions with one hour in between :
During the session 1 :
During the session 2:
We supposed that the performance of compulsive gamblers in words generation test will be higher than those of healthy volunteers, themselves superior to those of PD patients with a hyper-dopaminergic behavior, themselves superior to those of PD patient without hyper-dopaminergic behavior.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy volunteers | Other | evaluation of word generation and of motivation |
|
| compulsive gamblers | Other | evaluation of word generation and of motivation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| evaluation of word generation and of motivation | Other | Each subject will realize twice each test during 2 sessions with one hour in between : During the session 1 :
During the session 2:
|
| Measure | Description | Time Frame |
|---|---|---|
| Changement of number of mistake during the words generation test | one hour |
| Measure | Description | Time Frame |
|---|---|---|
| changement of number of uncorrected errors during the Stroop test which reflects the incapacity to inhibit the reading and that evaluates attention | one hour |
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Inclusion Criteria:
For healthy volunteers :
For compulsive gamblers :
Exclusion Criteria:
For healthy volunteers and compulsive gamblers :
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| Name | Affiliation | Role |
|---|---|---|
| Christine Brefel, MD | UH Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU toulouse | Toulouse | 31000 | France |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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|
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |