Slow recruitment, high drop-out

A two month intervention trial assessing the effect of Vetal Laban containing L. acidophilus on enhancing functional bowel wellbeing among subjects with irritable bowel syndrome (IBS).

Inclusion Criteria:

• Males and females aged 18 to 65 years
• Subjects fulfilling Rome III criteria for IBS
• Sufficient health and orientation for participating in the trial
• Obtained his/her informed consent after verbal and written information.
• Have a high probability for compliance with and completion of the study.
• Body Mass Index (BMI) between 19 and 35.

Exclusion Criteria:

• Diagnosed or suspected organic gastrointestinal disease (i.e. colitis, Crohn's disease, celiac disease, major bowel surgery, recurrent diverticulitis) or severely impaired general health including cancer and cancer therapy.
• Lactose intolerance
• Unwillingness to refrain from probiotic use during the trial
• Use of antibiotics within the 3 preceding months prior to recruitment
• Pregnant, planning pregnancy or lactating
• Expected major lifestyle changes related to nutrition, exercise, travelling etc.
• Participation in a clinical trial with an investigational product or drug within 3 months prior to screening.
• Substance abuse
• Subjects unable to read and understand the questionnaires