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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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This study will adapt Problem Solving Therapy (PST) for individuals with mild cognitive impairment (MCI) as an intervention for preventing major depression (DEP). PST will be modified so as to be provided to both MCI probands as well as their support person. The primary aim is to examine the effectiveness of PST in individuals with MCI and the support person, at preventing DEP over 12 mos. in MCI probands. We also will examine the effect of exercise on preventing depression.
The Recall Study (Retaining Cognition while Avoiding Late-Life Depression) is a study for adults 60 and older who have noticed mild memory changes in themselves or a loved one. Mild memory changes may feel stressful and therefore increase an individual's risk of developing depression. This research project will test whether Problem Solving Therapy (PST) is successful in preventing major depression for those living with mild cognitive impairments. We will also examine the effect of modest exercise on mood. You will participate in 8 to 12 PST sessions over 16 weeks. All treatments are provided at no cost and there is compensation for participation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Problem Solving Therapy | Active Comparator | 8-12 sessions of Problem Solving Therapy (both members of dyad) |
|
| Problem Solving Therapy + Exercise | Active Comparator | 6-12 sessions of Problem Solving Therapy + Exercise (both members of dyad) |
|
| Enhanced Usual Care | Active Comparator | Staff will will document and monitor all mental health treatment (e.g., medications that participant may be taking) and psychotherapy (e.g. counseling or social services). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Problem Solving Therapy | Behavioral | 6-12 sessions of Problem Solving Therapy (both members of dyad) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of depression or anxiety disorders | PHQ9, prime-MD SCID, GAD7 | 15 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cognitive function measured by RBANS and DKEFS | RBANS, DKEFS, 3MS, PASS, CAMCI, CIRS-G, RAND-12, LLFDI, SPPB, PSQI, NRS, ISEL, PROMIS, Cornell Services Index, P-GIC, ZARIT, DAS | 15 months |
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MCI participant Inclusion Criteria:
MCI participant Exclusion Criteria:
Support person Inclusion Criteria:
Support person Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Meryl Butters, MD | University of Pittsburgh | Principal Investigator |
| Ariel Gildengers, MD | University of Pittsburgh | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UPMC Late-Life Evaluation and Treatment Center | Pittsburgh | Pennsylvania | 15213 | United States | ||
| UPMC Western Psychiatric Institute and Clinic |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27066730 | Derived | Gildengers AG, Butters MA, Albert SM, Anderson SJ, Dew MA, Erickson K, Garand L, Karp JF, Lockovich MH, Morse J, Reynolds CF 3rd. Design and Implementation of an Intervention Development Study: Retaining Cognition While Avoiding Late-Life Depression (ReCALL). Am J Geriatr Psychiatry. 2016 Jun;24(6):444-54. doi: 10.1016/j.jagp.2015.10.010. Epub 2015 Nov 18. |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D008569 | Memory Disorders |
| D000084802 | Caregiver Burden |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D019954 | Neurobehavioral Manifestations |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Problem Solving Therapy + Exercise | Behavioral | 6-12 sessions of Problem Solving Therapy + Exercise (both members of dyad) |
|
| Enhanced Usual Care | Other | Staff will document and monitor all mental health treatment (e.g., medications that participant may be taking) and psychotherapy (e.g. counseling or social services). |
|
| Pittsburgh |
| Pennsylvania |
| 15213 |
| United States |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D013315 | Stress, Psychological |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |