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| Name | Class |
|---|---|
| Mayo Clinic | OTHER |
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The study is a crossover, pilot trial examining the acute effects of standing on blood sugar in prediabetic, working adults. Participants will complete oral glucose tolerance testing, once while sitting and once while standing. They will also wear a continuous blood sugar monitor once while sitting at their desk for a week and once while using their desk as a sit-stand desk with a goal of standing intermittently for at least half of the work day. Physical activity levels will be measured with an accelerometer. The primary study hypothesis is that blood sugar will differ between the sitting and standing conditions for each of the tests performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sitting Oral Glucose Tolerance Test | Placebo Comparator | An OGTT is performed while the subject sits at their desk for the entire 2-hour period. 5 blood sugar measurements are taken and a 75g dextrose beverage is consumed following the first, baseline blood sugar reading. The blood sugar is then measured every 30 minutes up to 120 min. |
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| Standing Oral Glucose Tolerance Test | Experimental | The participant stands at their desk for the duration of the 2-hour blood sugar test. The same procedure is performed as in the sitting condition. |
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| Sitting Continuous Glucose Monitor | Placebo Comparator | A continuous blood glucose monitor is worn for 5 days while at work. In the sitting condition the participant only sits at their desk for the duration of the week. Blood sugar is monitored 4 times per day to calibrate the CGM and an accelerometer is worn to track physical activity. |
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| Standing Continuous Glucose Monitor | Experimental | Participants are instructed to stand intermittently for at least half of their work day during this 5 day period. Blood sugar is monitored and physical activity is tracked with an accelerometer. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sitting OGTT | Other |
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| Standing OGTT |
| Measure | Description | Time Frame |
|---|---|---|
| Blood sugar area under the curve | The area under the curve following the 2 hour blood sugar tests. | 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Accelerometer counts | Accelerometer counts in the 4 testing conditions. | 4 hours and 2 5 day periods |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Human Services | Saint Paul | Minnesota | 55155 | United States |
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| ID | Term |
|---|---|
| D011236 | Prediabetic State |
| D057185 | Sedentary Behavior |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Other |
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| Sitting CGM | Other |
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| Standing CGM | Other |
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| D004700 | Endocrine System Diseases |
| D001519 | Behavior |