Third Molar Clinical Trials: Pericoronitis Studies

Pericoronitis; Oral and Systemic Inflammation

The purpose of this research study is to find out if the infection around 3rd molars and the resulting inflammation around the gum also produces a general systemic inflammation.

Relate signs and symptoms of mild pericoronitis, an oral clinical condition characterized by intense inflammation and pain around a lower 3rd molar, to indicators of oral and systemic inflammation in patients seeking treatment for the condition.

Inclusion Criteria:

• Mild signs/symptoms of pericoronitis affecting at least one lower 3rd molar with adjacent 2nd molar (spontaneous pain with localized swelling, purulence/drainage) with recommended treatment being removal of 3rd molars,
• Age 18 - 35 years,
• ASA I, II health status,
• AAP 1-3 periodontal status,
• Willingness to participate in the study,
• Geographic proximity to UNC.

Exclusion Criteria:

• Major signs/symptoms of pericoronitis (Temperature >101 , dysphagia, limited mouth opening <20mm incisor, facial swelling/cellulitis, severe uncontrolled discomfort),
• ASA III, IV health status,
• Medical contraindication to full mouth periodontal probing,
• AAP 4 periodontal status,
• Antibiotic treatment within the past 2 months,
• Current tobacco use,
• BMI > 29,
• Pregnancy,
• Non English speaking.