To treat patients with scleroderma by blocking the expression of LOXL2. The investigators first need to confirm (through observation) that LOXL2 is overexpressed in disease.

Scleroderma is a chronic skin-hardening disease. There are two types of scleroderma. The first type is called limited cutaneous scleroderma, where disrupted blood flow causes skin discoloration and sometimes patients experience high blood pressure in their arteries. The second type is called diffuse cutaneous scleroderma and it is much more aggressive, affecting a larger area of skin causing organ damage. This study will determine if the disease is associated with an elevated expression of LOXL2 levels in tissue samples from patients.

Inclusion Criteria:

• Over 18 years of age
• Documented diagnosis of scleroderma
• Willing and able to provide written informed consent

Exclusion Criteria:

• Use of experimental therapies within 28 days prior to Screening.
• Aspirin use > 81 mg daily within 1 week prior to Screening.
• Any lab abnormality or concurrent medical condition that, in the opinion of the investigator would make the patient ineligible for the study

Adult subjects with documented diagnoses of scleroderma will be enrolled into one of two cohorts, depending upon the subject's diagnosis