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Early detection of breast cancer through screening has been a common practice in the United States and several European countries for decades.It is effective in reducing the mortality of breast cancer and improving the postoperative quality of life of patients. Mammography has been the standard imaging method for the screening, and in recent years, a supplemental ultrasound exam is also recommended.A prospective, multi-center, randomized trial is needed to define an optimal screening strategy that suits Chinese women and the socioeconomics of China.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 | Experimental | screening with mammography alone |
|
| group 2 | Experimental | screening with ultrasonography alone |
|
| group 3 | Experimental | screening with both mammography and ultrasound |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mammography | Other | participants were screened by mammography alone every year |
| |
| Measure | Description | Time Frame |
|---|---|---|
| screening yield | Sensitivities, specificities, positive predictive values, and negative predictive values | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Cost-effectiveness | cost of each screening modility to detect one cancer | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sun Qiang, MD | PUMCH | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking Union Medical College Hospital | Beijing | Beijing Municipality | 100730 | China | ||
| Beijing ChaoYang Hospital affiliated to the Capital Medical University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25668012 | Derived | Shen S, Zhou Y, Xu Y, Zhang B, Duan X, Huang R, Li B, Shi Y, Shao Z, Liao H, Jiang J, Shen N, Zhang J, Yu C, Jiang H, Li S, Han S, Ma J, Sun Q. A multi-centre randomised trial comparing ultrasound vs mammography for screening breast cancer in high-risk Chinese women. Br J Cancer. 2015 Mar 17;112(6):998-1004. doi: 10.1038/bjc.2015.33. |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D019220 | High-Energy Shock Waves |
| ID | Term |
|---|---|
| D000069453 | Ultrasonic Waves |
| D013016 | Sound |
| D011840 | Radiation, Nonionizing |
| D011827 | Radiation |
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| ultrasound |
| Other |
participants were screened by ultrasound alone every year |
|
| mammography and ultrasound | Other | Participants were screened by both mammography and ultrasound every year |
|
| Beijing |
| Beijing Municipality |
| China |
| Beijing Hospital affiliated to Ministry of Health | Beijing | Beijing Municipality | China |
| Chinese 307 Hospital affiliated to the People's Liberation Army | Beijing | Beijing Municipality | China |
| First Hospital affiliated to Peking University | Beijing | Beijing Municipality | China |
| The Cancer Institute & Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences | Beijing | Beijing Municipality | China |
| The General Hospital affiliated to Beijing Military Area Command | Beijing | Beijing Municipality | China |
| Southwest Hospital affiliated to the Third Military Medical University | Chongqing | Chongqing Municipality | China |
| Population and Family Planning Service Center of Zhuhai | Zhuhai | Guangdong | China |
| Maternity & Child Care Center of Qinhangdao | Qinhuangdao | Hebei | China |
| YingBin Surgery Hospital of Yancheng | Yancheng | Jiangsu | China |
| The Cancer Hospital affiliated to Fudan University | Shanghai | Shanghai Municipality | China |
| ShanXi Traditional Medicine Hospital | Taiyuan | Shanxi | China |
| The Cancer Hospital affiliated to Tianjin Medical University | Tianjin | Tianjin Municipality | China |
| D017437 |
| Skin and Connective Tissue Diseases |
| D055585 |
| Physical Phenomena |