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The purpose of this study is to determine whether synthetic hernia mesh materials undergo physical and/or chemical changes while in the body.
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| Measure | Description | Time Frame |
|---|---|---|
| Fibrosis level of explanted mesh | Each specimen will be graded and given fibrosis score of 0 - 4 to establish the degree of inflammation/foreign body reaction that occurred while mesh was in vivo. | Within 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Tensile strength of explanted mesh | Each specimen will be tested for tensile strength to determine force versus displacement. | Within 2 weeks |
| Collagen protein levels of explanted mesh. | The total amount of collagen and non-collagenous proteins in cultured cell layers and tissue sections by differential staining with two dyes, sirius red and fast green. Sirius Red binds to all types of collagen, whereas fast green stains non-collagenous proteins. |
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Inclusion criteria:
Exclusion criteria:
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Subjects will be recruited from study investigators' patient population.
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| Name | Affiliation | Role |
|---|---|---|
| Michael Brunt, MD | Washington University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Washington University School of Medicine | St Louis | Missouri | 63110 | United States |
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| Within 2 weeks |
| Number of subjects with history of radiation to abdomen/pelvis | Identify possible clinical characteristics which affect mesh degradation. | Within 2 weeks |
| Number of subjects with history of chemotherapy | Identify possible clinical characteristics which affect mesh degradation. | Within 2 weeks |
| Number of subjects with corticosteroid/immunosuppression therapy | Identify possible clinical characteristics which affect mesh degradation. | Within 2 weeks |
| Number of subjects with history of tobacco use | Identify possible clinical characteristics which affect mesh degradation. | Within 2 weeks |