Regenerative Medicine of Articular Cartilage: Characterization and Comparison of Chondrogenic Potential and Immunomodulatory Adult Mesenchymal Stem Cells

Regenerative Medicine of Articular Cartilage: Characterization and Comparison of Chondrogenic Potential and Immunomodulatory Adult Mesenchymal Stem Cells

Articular cartilage can be the seat of many diseases including osteoarthritis and traumatic defaults. The cartilage has no intrinsic ability to repair resulting at long term in function loss in the joints. Currently available treatments are not satisfactory in the long term, the use of mesenchymal stem cells appears to be promising due to their ability to multipotency and immunomodulation properties. This project aims to determine the most appropriate source for regenerative medicine of cartilage stem cells from tissue taken during arthroplasty in patients with osteoarthritis. These cells will be tested for different chondrogenic markers. The success of this project will consider the implementation of a strategy for regenerative medicine in bone and joint diseases.

Inclusion Criteria:

• Patients aged over 18 years
• Patients with knee osteoarthritis
• Patients requiring total knee arthroplasty
• Patients who signed the consent form

Exclusion Criteria:

• Patients aged less than 18 years
• Major Patients under guardianship
• Pregnant woman
• Infectious pathology or progressive tumor
• Refusal to participate in the study
• State of immunosuppression
• Congenital or acquired malformation resulting in a deformation of the knee