Effects of N-acetyl Cysteine During Percutaneous Coronary Intervention

Effects of N-acetyl Cysteine on Periprocedural Myocardial Infarction and Major Cardiac and Cerebral Events in Patients Undergoing Percutaneous Coronary Intervention

The aim of this study is to evaluate the effects of N-acetyl cysteine on periprocedural myocardial infarction and major cardiac and cerebral events in patients undergoing percutaneous coronary intervention and who have moderate to high risk for contrast induced nephropathy.

Inclusion Criteria:

• Patients > 18 years old undergoing percutaneous coronary intervention and who have moderate to high risk for contrast induced nephropathy (Mehran Score ≥ 5)

Exclusion Criteria:

• Primary percutaneous coronary intervention
• Low risk for contrast induced nephropathy (Mehran Score < 5)
• Use of nephrotoxic agents (NSAIDs, aminoglycosides,recent contrast injection...)
• Infection
• Pregnancy, Lactation
• Renal failure requiring dialysis
• Hepatic failure
• History allergy for NAC
• History of Asthma
• Chronic nitrate usage
• Malignancy
• Use of corticosteroids
• Leukocytosis,Thrombocytosis,Anemia
• Blood pressure of >180/100mmHg despite anti-hypertensive therapy