Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit

Pilot Study of the Effects of Inhaled Antibiotic on Bacterial Resistance

The purpose of this study was :

• to determine the effect of inhaled antibiotics on airway bacteria in ventilated patients
• to determine the effect of inhaled antibiotics on respiratory infection

Double-blind randomized placebo controlled study examining the effect of aerosolized antibiotics on respiratory infection signs and symptoms and on bacterial eradication and resistance.

Systemic antibiotics are administered by the responsible physician

Inclusion Criteria:

• be on mechanical ventilation greater than 3 days
• greater than or equal to 18 years and survival greater than 14 days
• organisms on Gram stain with increasing purulent secretions

Exclusion Criteria:

• pregnancy
• allergy to drugs administered