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| Name | Class |
|---|---|
| Meda Pharmaceuticals | INDUSTRY |
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The proposed study will evaluate the unmet therapy need in seasonal rhinitis by aiming to answer the following research questions
Allergic rhinitis is a chronic respiratory disease with a major impact on quality of life. In a study looking at the burden of allergic rhinitis amongst UK patients 75% reported some impact of their allergic rhinitis symptoms on health-related quality of life. Allergic rhinitis currently affects 10-30% of the world population with prevalence and impact continuing to increase. This leads to substantial economic costs both of prescription medication and time taken off work by both patients and carers due to the disease. In view of this, there may be a substantial need for improved therapy or management to ensure that patients with allergic rhinitis can carry out a normal lifestyle.
The proposed study will evaluate the unmet therapy need in seasonal rhinitis by examining the current medication requirements of patients who suffer from seasonal grass-pollen hay fever and determining whether current therapies are sufficient for managing rhinitis.
This study aims to evaluate the unmet therapy need in seasonal rhinitis by -
for managing and controlling seasonal rhinitis in primary care patients who suffer from seasonal grass-pollen hay fever.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Persistent Patients | Defined as those with ≥1 treatment for allergic rhinitis in the six months preceding the IPD (defined as the first script of the hay fever season - May to August) | ||
| Seasonal Rhinitis | No treatment for allergic rhinitis in the six months preceding the IPD |
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| Measure | Description | Time Frame |
|---|---|---|
| Co-prescribing | The proportion of patients managed at the index prescription date with more than one class of therapy | 31.11.12 |
| Treatment Outcomes | For those patients who receive a prescription for a diagnosis of seasonal rhinitis/ hay fever. The following outcomes will be measured -
| 10.12.12 |
| Number of Consultations | Defined as a consultation where an allergic rhinitis read code or hay fever code is recorded during the hay fever season. | 10.12.12 |
| Asthma Patients - Exacerbations: Clinical | where exacerbation is defined as an occurrence of the following: a)Lower respiratory related : Hospital attendance/admission OR A & E attendance; OR Out-of-hours attendance;
| 10.12.12 |
| Asthma Patients - Exacerbations: Severe | b)Asthma related - Hospital attendance/admission OR A & E attendance; OR Out-of-hours attendance; GP consultations for asthma related tract infections; Acute use of oral steroids | 10.12.12 |
| Costing Analysis | Descriptive analysis of costs at the first prescription and final prescription of the season. Comparing those who remain on same therapy and those who add therapy during the season. | 15.01.13 |
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Inclusion Criteria
The analysis will include patients who, at the index date, receive a therapy prescription for allergic rhinitis and have been diagnosed with a hay fever read code during their time at the practice. The following patients will be included within the study population:
(i)Patients receiving therapy: defined as those with a prescription for the increase or initiation of hay fever therapy during the hay fever season
(ii)Hay-fever code recorded ever
Exclusion criteria
(i)Patients taking maintenance oral steroids during the baseline period
(ii)Patients who only received LTRA during the study period and had already been receiving LTRA previously
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Patients will have seasonal rhinitis: defined as hay fever/rhinitis diagnosis during the hay fever season period and will be receiving therapy during the hay fever season
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| Name | Affiliation | Role |
|---|---|---|
| David Price, Prof, MD | University of Aberdeen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research in Real Life Ltd | Cambridge | CB24 3BA | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15080802 | Background | Gupta R, Sheikh A, Strachan DP, Anderson HR. Burden of allergic disease in the UK: secondary analyses of national databases. Clin Exp Allergy. 2004 Apr;34(4):520-6. doi: 10.1111/j.1365-2222.2004.1935.x. | |
| 18622524 | Result | Van Cauwenberge P, Van Hoecke H, Kardos P, Price D, Waserman S. The current burden of allergic rhinitis amongst primary care practitioners and its impact on patient management. Prim Care Respir J. 2009 Mar;18(1):27-33. doi: 10.3132/pcrj.2008.00042. |
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| ID | Term |
|---|---|
| D012220 | Rhinitis |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D009668 | Nose Diseases |
| D012140 | Respiratory Tract Diseases |
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| 21277528 | Result | Meltzer EO, Bukstein DA. The economic impact of allergic rhinitis and current guidelines for treatment. Ann Allergy Asthma Immunol. 2011 Feb;106(2 Suppl):S12-6. doi: 10.1016/j.anai.2010.10.014. |
| D010038 |
| Otorhinolaryngologic Diseases |