Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
15 volunteers will be investigated for their hypoxic and hypercapnic ventilatory response during sedation with dexmedetomidine and propofol in a randomized cross-over study.
6 volunteers will be investigated for their repeated response to hypoxia and hypercapnia in order to validate the method.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sedation with dexmedetomidine | Experimental | Sedation with dexmedetomidine |
|
| Sedation with propofol | Experimental | Sedation with propofol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypoxic ventilatory response | Procedure |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Hypoxic ventilatory response | Acute hypoxic ventilatory response,i.e. the ventilatory response to acute hypoxia measured as change in minute ventilation over change in peripheral oxygen saturation | One day for each drug; before,during and after sedation with dexmeditomidine or propofol |
| Measure | Description | Time Frame |
|---|---|---|
| hypercapnic ventilatory response | The acute ventilatory response to hypercapnia, i.e. change in minute ventilation over change in end-tidal carbon dioxide | One day for each drug; Before, during and after sedation with dexmedetomidine or propofol |
| Measure | Description | Time Frame |
|---|---|---|
| upper airway obstruction | Objective signs of upper airway obstruction, e.g. Interruption of airflow at the same time as breathing movements of the thoracic wall, paradoxal breathing, increased airway resistance | One day for each drug: Before, during and after sedation with dexmedetomidine or propofol |
| Plasma concentration |
Inclusion Criteria:
Exclusion Criteria:
Snoring
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Malin Jonsson Fagerlund, MD, PhD | Karolinska University Hospital and Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital | Stockholm | SE-17176 | Sweden |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Hypercapnic ventilatory response |
| Procedure |
|
|
Plasma concentration of dexmedetomidine or propofol |
| One day for each drug; At target sedation |
| Sedation level | Sedation level will be measured as Richmond Agitation Sedation Scale(RASS) the observer's assessment of alertness/sedation scale (OAA/S) | One day; During the whole experimental procedure |
| Bispectral index | Bispectral index (BIS) gives a number between 0-100 | One day; During the whole experimental procedure |
| ID | Term |
|---|---|
| D000860 | Hypoxia |
| D006935 | Hypercapnia |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided