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Patients of vascular cognitive impairment-no dementia (VCIND) in one group is prescribed cilostazol,in the other group is prescribed aspirin. Evaluate both of them in cognitive function, MRI and other sides at given time. The investigators hypothesize that cilostazol is more efficient and safer than aspirin in patients with VCIND.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aspirin | Active Comparator | Aspirin, 100mg, Q.D, p.o, 2yr |
|
| Cilostazol | Experimental | cilostazol, 100mg, B.I.D, p.o, 2yr |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aspirin | Drug | Aspirin, 100mg, Q.D, p.o, 2yr |
| |
| Cilostazol |
| Measure | Description | Time Frame |
|---|---|---|
| changes in cognitive function | scores in Montreal Cognitive Assessment,Mini-Mental Status Examination, Clinal Dementia Rating,trail making test, similarity test, Stroop test. | baseline, 3month, 6month, 1year, and 2year |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with Incident cerebral vascular event | including cerebral infarct, cerebral hemorrhage, transient ischemic attack. | 3month, 6month, 1year and 2year |
| Changes of peripheral inflammatory markers level |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Neurology, Huashan Hospital, Fudan University | Recruiting | Shanghai | Shanghai Municipality | 200040 | China |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| D000077407 | Cilostazol |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
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| Drug |
cilostazol, 100mg, B.I.D, p.o, 2yr |
|
intercellular adhesion molecules(ICAM), thrombomodulin, tissue factor(TF), tissue factor plasma inhibitor,TFPI, etc.
| baseline, 2year |
| The progression of cerebral white matter lesion and lacunar infarction | baseline, 3month, 6month, 1year and 2year |
| changes in MRI-diffused tension image(DTI) | cerebral volume , lacune infarct, white matter lesion, micro-bleed, apparent diffusion coefficient(ADC) . | baseline, 2year |
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013777 | Tetrazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011804 | Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |