Effect of 10-day Overnight Hypoxia Treatment on Whole Body Insulin Sensitivity (SLEEP HIGH Study)

Effect of 10-day Overnight Hypoxia Treatment on Whole Body Insulin Sensitivity (SLEEP HIGH Study)

The purpose of this study is to look at how a reduction in oxygen levels (hypoxia) influences insulin sensitivity and carbohydrate metabolism. It is expected that 10 nights of exposure to moderate hypoxia (~ 15% O2, similar to conditions at an altitude of ~7500 feet) will improve glucose metabolism.

Inclusion Criteria:

• Aged 20-45 years
• Male
• Obese category (BMI > 30 kg/m2)
• Healthy as assessed by a self-reported health questionnaire
• Non-smokers
• Weight stable over the past 3 months (<2kg fluctuation)

Exclusion Criteria:

• Female
• Diabetes
• Sleep apnea
• Hypertension
• History of altitude sickness
• Individuals taking any chronic medications
• Individuals taking any stimulants
• Individuals taking beta-blockers
• Individuals with chronic alcohol consumption (>3 drinks per day) or drug abuse.
• Individuals unable to abstain from caffeinated beverage or alcohol the days of study testing
• Individuals with history disease or history of stroke