Lactobacillus Reuteri in Adult With Functional Chronic Constipation

The Effect of Lactobacillus Reuteri Supplementation to Adult With Functional Chronic Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial

A double-blind, placebo Randomized Controlled Trial, To evaluate the effects of L. reuteri in adult patients with functional constipation.

Patients affected by functional constipation according to Rome III criteria. The increase of Bowel Movements/week frequency was the primary outcome, while the improvement of stool consistency was the secondary outcome.

Inclusion Criteria:

• functional constipation rome III

Exclusion Criteria:

• hypothyroidism or other metabolic or renal abnormalities, or
• antibiotic's treatment,
• probiotic or prebiotic supplementation in the last month